PM&R
Volume 2, Issue 7 , Pages 636-641 , July 2010

The Effects of a Brief Relaxation Program on Symptom Distress and Heart Rate Variability in Cancer Patients

Portions of this work presented at the AAPM&R Annual Assembly in October 2009

  • Arash Asher, MD

      Affiliations

    • Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, C-2000, Los Angeles, CA 90048
    • Corresponding Author InformationAddress correspondence to: A.A.
  • ,
  • J. Lynn Palmer, PhD

      Affiliations

    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • ,
  • Rajesh R. Yadav, MD

      Affiliations

    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • ,
  • Syed W. Yusuf, MD

      Affiliations

    • Department of Cardiology, The University of Texas M.D. Anderson Cancer Center, Houston, TX§
  • ,
  • Benedict Konzen, MD

      Affiliations

    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • ,
  • Eduardo Bruera, MD

      Affiliations

    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
  • ,
  • Ying Guo, MD

      Affiliations

    • Department of Palliative Care and Rehabilitation Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX#

Received 30 October 2009 ,Accepted 27 April 2010.

References 

  1. Caudell KA. Psychoneuroimmunology and innovative behavioral interventions in patients with leukemia. Oncol Nurs Forum. 1996;23:493–502
  2. Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol. 2000;18:2505–2514
  3. Vapiwala N, Mick R, Hampshire MK, Metz JM, DeNittis AS. Patient initiation of complementary and alternative medical therapies (CAM) following cancer diagnosis. Cancer J. 2006;12:455–458
  4. Burstein HJ, Gelber S, Guadagnoli E, Weeks JC. Use of alternative medicine by women with early-stage breast cancer. N Engl J Med. 1999;340:1733–1739
  5. Newell S, Sanson-Fisher RW. Australian oncologists' self-reported knowledge and attitudes about non-traditional therapies used by cancer patients. Med J Aust. 2000;172:110–113
  6. Walker LG, Heys SD, Walker MB, et al. Psychological factors can predict the response to primary chemotherapy in patients with locally advanced breast cancer. Eur J Cancer. 1999;35:1783–1788
  7. Kolcaba K, Fox C. The effects of guided imagery on comfort of women with early stage breast cancer undergoing radiation therapy. Oncol Nurs Forum. 1999;26:67–72
  8. Fleet SV. Relaxation and imagery for symptom management: Improving patient assessment and individualizing treatment. Oncol Nurs Forum. 2000;27:501–510
  9. Redd WH, Montgomery GH, DuHamel KN. Behavioral intervention for cancer treatment side effects. J Natl Cancer Inst. 2001;93:810–823
  10. Sloman R. Relaxation and imagery for anxiety and depression control in community patients with advanced cancer. Cancer Nurs. 2002;25:432–435
  11. Leon-Pizarro C, Gich I, Barthe E, et al. A randomized trial of the effect of training in relaxation and guided imagery in improving psychological and quality-of-life indices for gynecologic and breast brachytherapy patients. Psychooncology. 2007;16:971–979
  12. Terathongkum S, Pickler RH. Relationships among heart rate variability, hypertension, and relaxation techniques. J Vasc Nurs. 2004;22:78–82
  13. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Circulation. 1996;93:1043–1065
  14. Stein PK, Mietus JE, Goldberger AL. Heart rate variability: Uses other than after myocardial infarction (UpToDate, Waltham, MA). http://www.uptodate.com/patients/content/topic.do?topicKey=∼GKlHGSiIsiBBDVG2009;Accessed May 13, 2010
  15. Vrijkotte TG, van Doornen LJ, de Geus EJ. Effects of work stress on ambulatory blood pressure, heart rate, and heart rate variability. Hypertension. 2000;35:880–886
  16. Van Dixhoorn J, White A. Relaxation therapy for rehabilitation and prevention in ischaemic heart disease: A systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2005;12:193–202
  17. Sakakibara M, Takeuchi S, Hayano J. Effect of relaxation training on cardiac parasympathetic tone. Psychophysiology. 1994;31:223–228
  18. Peng C-K, Mietus JE, Liu Y, et al. Exaggerated heart rate oscillations during two meditation techniques. Int J Cardiol. 1999;70:101–107
  19. Kamath MV, Halton J, Harvey A, Turner-Gomes S, McArthur AB. Cardiac autonomic dysfunction in survivors of acute lymphoblastic leukemia in childhood. Int J Oncol. 1998;12:635–640
  20. Bruera E, Kuehn N, Miller MJ, Selmser P, Macmillan K. The Edmonton Symptom Assessment System (ESAS): A simple method for the assessment of palliative care patients. J Palliat Care. 1991;7:6–9
  21. Weiss BL. Through Time Into Healing. 1st ed.. New York, NY: Fireside; 1992;
  22. Zhong X, Hilton HJ, Gates GJ, et al. Increased sympathetic and decreased parasympathetic cardiovascular modulation in normal humans with acute sleep deprivation. J Appl Physiol. 2005;98:2024–2032
  23. Goldberger JJ. Sympatho-vagal balance: How should we measure it?. Am J Physiol. 1999;276:1273–1280
  24. Folwell M, Burman D, Le LW, et al. Phase II study of an outpatient palliative care intervention in patients with metastatic cancer. J Clin Oncol. 2008;27:206–213
  25. Ringash J, O'Sullivan B, Bezjak A, Redelmeier DA. Interpreting clinically significant changes in patient-reported outcomes. Cancer. 2007;110:196–202
  26. Barrett B, Brown D, Mundt M, Brown R. Sufficiently important difference: Expanding the framework of clinical significance. Med Decis Making. 2005;25:250–261
  27. Richardson LA, Jones GW. A review of the reliability and validity of the Edmonton Symptom Assessment System. Curr Oncol. 2009;16:53–64
  28. Nekolaichuk C, Watanabe S, Beaumont C. The Edmonton Symptom Assessment System: A 15-year retrospective review of validation studies (1991-2006). Palliat Med. 2008;22:111–122
  29. Vempati RP, Telles S. Yoga-based guided relaxation reduces sympathetic activity judged from baseline levels. Psychol Rep. 2002;90:487–494
  30. Kemper KJ, Hamilton CA, Mclean TW, Lovato J. Impact of music on pediatric oncology outpatients. Pediatr Res. 2008;64:105–109
  31. Walsh D, Nelson KA. Autonomic nervous system dysfunction in advanced cancer. Support Care Cancer. 2002;10:523–528
  32. Strasser F, Palmer JL, Schover LR, et al. The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study. Cancer. 2006;107:2949–2957
  33. Hejjel L, Gal I. Heart rate variability analysis. Acta Physiol Hung. 2001;88:219–230
  34. Ergun U, Demirci M, Nurlu G, Komurcu F. Power spectral analysis of heart rate variability: Normal values of subjects over 60 years old. Int J Neurosci. 2008;118:1165–1173
  35. Liu W, Lian Z, Liu Y. Heart rate variability at different thermal comfort levels. Eur J Appl Physiol. 2008;103:361–366
  36. Bleil MA, Gianaros PJ, Jennings R, Flory JD, Manuck SB. Trait negative affect: Toward an integrated model of understanding psychological risk for impairment in cardiac autonomic function. Psychosom Med. 2009;70:328–337

PII: S1934-1482(10)00378-3

doi: 10.1016/j.pmrj.2010.04.026

PM&R
Volume 2, Issue 7 , Pages 636-641 , July 2010