PM&R
Volume 2, Issue 7 , Pages 607-611 , July 2010

Hypoesthesia in the Distal Residual Limb of Amputees

  • R. Norman Harden, MD

      Affiliations

    • Center for Pain Studies, Rehabilitation Institute of Chicago, 446 E. Ontario, Suite 1011, Chicago, IL 60611; Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL⁎
    • Corresponding Author InformationAddress correspondence to: R.N.H.
    • ,
  • Christine M. Gagnon, PhD

      Affiliations

    • Center for Pain Studies, Rehabilitation Institute of Chicago, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL†
    • ,
  • Anjum Khan, MD

      Affiliations

    • Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, IL‡
    • ,
  • Gila Wallach, PhD

      Affiliations

    • Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, IL§
    • ,
  • Arzhang Zereshki, MD

      Affiliations

    • Center for Pain Studies, Rehabilitation Institute of Chicago, Chicago, IL∥

Received 4 November 2009 ,Accepted 12 March 2010.

References 

  1. Kosasih JB, Silver-Thorn MB. Sensory changes in adults with unilateral transtibial amputation. J Rehabil Res Dev. 1998;35:85–90
  2. Carlen PL, Wall PD, Nadvorna H, Steinbach T. Phantom limbs and related phenomena in recent traumatic amputations. Neurology. 1978;28:211–217
  3. Loseth S, Lindal S, Stalberg E, Mellgren SI. Intraepidermal nerve fibre density, quantitative sensory testing and nerve conduction studies in a patient material with symptoms and signs of sensory polyneuropathy. Eur J Neurol. 2006;13:105–111
  4. Hunter JP, Katz J, Davis KD. Dissociation of phantom limb phenomena from stump tactile spatial acuity and sensory thresholds. Brain. 2005;128:308–320
  5. Harden RN, Khan AS, Gagnon CM, Daschbach P, DiMaio A, Kiuken T. Poster 148: The assessment of quantitative sensory testing in postamputation patients. Arch Phys Med Rehabil. 2006;87:E39
  6. Braune S, Schady W. Changes in sensation after nerve injury or amputation: The role of central factors. J Neurol Neurosurg Psychiatry. 1993;56:393–399
  7. Harden R, Khan A, Zinke J, DiMaio A, Gagnon C. Abstract 845: Distal residual limbs in amputees show significant cold perception hypoesthesia. J Pain. 2006;7:S62
  8. Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain: Diagnosis, mechanisms, and treatment recommendations. Arch Neurol. 2003;60:1524–1534
  9. Rolke R, Magerl W, Campbell KA, et al. Quantitative sensory testing: A comprehensive protocol for clinical trials. Eur J Pain. 2006;10:77–88
  10. Gruener G, Dyck PJ. Quantitative sensory testing: methodology, applications, and future directions. J Clin Neurophysiol. 1994;11:568–583
  11. Weinberg SL, Abramowitz SK. Data analysis for the behavioral sciences using SPSS. Cambridge, UK: Cambridge University Press; 2002;
  12. Montell C. Thermosensation: Hot findings make TRPNs very cool. Curr Biol. 2003;13:R476–R478
  13. Story GM, Peier AM, Reeve AJ, et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003;112:819–829
  14. Kandel ER, Schwartz JH, Jessell TM. Principles of Neural Science. 4th ed.. New York: McGraw-Hill, Health Professions Division; 2000;
  15. Craig AD. Pain mechanisms: Labeled lines versus convergence in central processing. Annu Rev Neurosci. 2003;26:1–30
  16. Harden RN, Gagnon CM, Gallizzi M, Khan AS, Newman D. Residual limbs of amputees are significantly cooler than contralateral intact limbs. Pain Pract. 2008;8:342–347
  17. Crews JC, Cahall MA. An investigation of the neurophysiologic mechanisms of tourniquet-related pain: Changes in spontaneous activity and receptive field size in spinal dorsal horn neurons. Reg Anesth Pain Med. 1999;24:102–109

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(10)00302-3

doi: 10.1016/j.pmrj.2010.03.033

PM&R
Volume 2, Issue 7 , Pages 607-611 , July 2010

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