PM&R
Volume 2, Issue 5 , Pages 332-337 , May 2010

Central Fatigue: Issues Related to Cognition, Mood and Behavior, and Psychiatric Diagnoses

  • Victoria M. Leavitt, PhD

      Affiliations

    • Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ†
    • ,
  • John DeLuca, PhD

      Affiliations

    • Kessler Foundation, 300 Executive Drive, Suite 150, West Orange, NJ 07052‡
    • Corresponding Author InformationAddress correspondence to: J.D.L.

Received 19 January 2010 ,Accepted 21 March 2010.

References 

  1. DeLuca J. Fatigue as a window to the brain. Cambridge, MA: The MIT Press; 2005;
  2. Wessely S, Hotopf M, Sharpe M. Chronic fatigue and its syndromes. New York: Oxford University Press; 1998;
  3. Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sci. 2000;179:34–42
  4. Gandevia SC, Allen GM, Butler JE, Taylor JL. Supraspinal factors in human muscle fatigue: evidence for suboptimal output from the motor cortex. J Physiol. 1996;490:529–536
  5. Gandevia SC, Allen GM, Butler JE, Taylor JL. Supraspinal factors in human muscle fatigue: Evidence for suboptimal output from the motor cortex. J Physiol (London). 1996;490:529–536
  6. Gandevia SC, Butler JE, Allen GM, Taylor JL. Prolongation of the silent period following transcranial magnetic stimulation during human muscle fatigue. J Physiol. 1994;480:110P
  7. Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978–988
  8. Bryant D, Chiaravalloti ND, DeLuca J. Objective measurement of cognitive fatigue in multiple sclerosis. Rehab Psychol. 2004;49:114–122
  9. Mosso A. Fatigue. London: Swan Sonnenschein and Co; 1904;
  10. Ackerman PL, Kanfer R. Test length and cognitive fatigue: An empirical examination of effects on performance and test-taker reactions. J Exp Psychol Appl. 2009;15163–15181
  11. Johnson SK, Lange G, DeLuca J, Korn LR, Natelson B. The effects of fatigue on neuropsychological performance in patients with chronic fatigue syndrome, multiple sclerosis, and depression. Appl Neuropsychol. 1997;4:145–153
  12. Paul RH, Beatty WW, Schneider R, Blanco CR, Hames KA. Cognitive and physical fatigue in multiple sclerosis: Relations between self-report and objective performance. Appl Neuropsychol. 1998;5:143–148
  13. DeLuca J. Fatigue: Its definition, its study and its future. In:  DeLuca J editors. Fatigue as a Window to the Brain. Cambridge: MIT Press; 2005;p. 319–325
  14. Ziino C, Ponsford J. Selective attention deficits and subjective fatigue following traumatic brain injury. Neuropsychology. 2006;20:383–390
  15. Ziino C, Ponsford J. Vigilance and fatigue following traumatic brain injury. J Int Neuropsychol Soc. 2006;12:100–110
  16. Morrow SA, Weinstock-Guttman B, Munschauer FE, Hojnacki D, Benedict RH. Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: Cross-sectional and longitudinal analysis. Multiple Sclerosis (Houndmills, Basingstoke, England). 2009;15:998–1005
  17. Bailey A, Channon S, Beaumont JG. The relationship between subjective fatigue and cognitive fatigue in advanced multiple sclerosis. Multiple Sclerosis (Houndmills, Basingstoke, England). 2007;13:73–80
  18. Parmenter BA, Denney DR, Lynch SG. The cognitive performance of patients with multiple sclerosis during periods of high and low fatigue. Multiple Sclerosis (Houndmills, Basingstoke, England). 2003;9:111–118
  19. Nauta WJH. The relationship of basal ganglia to the limbic system. In:  Vinken PJ,  Bruyn GW editor. Handbook of Clinical Neurology. Amsterdam: Elsevier Science; 1986;p. 19–32
  20. Marrie RA, Fisher E, Miller DM, Lee JC, Rudick RA. Association of fatigue and brain atrophy in multiple sclerosis. J Neurol Sci. 2005;228:161–166
  21. Bakshi R, Miletich RS, Henschel K, et al. Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients. Neurology. 1999;53:1151–1153
  22. Tartaglia MC, Narayanan S, Francis SJ, et al. The relationship between diffuse axonal damage and fatigue in multiple sclerosis. Arch Neurol. 2004;61:201–207
  23. Tellez N, Alonso J, Rio J, et al. The basal ganglia: a substrate for fatigue in multiple sclerosis. Neuroradiology. 2008;50:17–23
  24. van der Werf SP, Jongen PJ, Lycklama a Nijeholt GJ, Barkhof F, Hommes OR, Bleijenberg G. Fatigue in multiple sclerosis: Interrelations between fatigue complaints, cerebral MRI abnormalities and neurological disability. J Neurol Sci. 1998;160:164–170
  25. Roelcke U, Kappos L, Lechner-Scott J, et al. Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: A 18F-fluorodeoxyglucose positron emission tomography study. Neurology. 1997;48:1566–15671
  26. Filippi M, Rocca MA, Colombo B, et al. Functional magnetic resonance imaging correlates of fatigue in multiple sclerosis. NeuroImage. 2002;15:5595-5567
  27. DeLuca J, Genova HM, Hillary FG, Wylie G. Neural correlates of cognitive fatigue in multiple sclerosis using functional MRI. J Neurol Sci. 2008;270:28–39
  28. Kohl AD, Wylie GR, Genova HM, Hillary FG, Deluca J. The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI. Brain Inj. 2009;23:420–432
  29. Siegel SD, Schneiderman N. Heart disease, cardiovascular functioning, and fatigue. In:  DeLuca J editors. Fatigue as a Window to the Brain. Cambridge, MA: MIT Press; 2005;
  30. Newsholme EA, Blomstrand E. Tryptophan, 5-hydroxytryptamine and a possible explanation for central fatigue. Adv Exp Med Biol. 1995;384:315–320
  31. Norra C, Becker S, Herpertz SC, Kunert HJ. Effects of experimental acute tryptophan depletion on acoustic startle response in females. Eur Arch Psychiatry Clin Neurosci. 2008;258:1–9
  32. Johnson , DeLuca J. Chronic fatigue syndrome and the brain. In:  DeLuca J editors. Fatigue as a Window to the Brain. Cambridge, MA: The MIT Press; 2005;p. 137–156
  33. Duntley S. Fatigue and sleep. In:  DeLuca J editors. Fatigue as a Window to the Brain. Cambridge: MIT Press; 2005;p. 210–227
  34. The International Classification of Sleep Disorders: Diagnostic and Coding Manual. Rochester, MN: American Academy of Sleep Medicine; 2000;

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(10)00295-9

doi: 10.1016/j.pmrj.2010.03.027

PM&R
Volume 2, Issue 5 , Pages 332-337 , May 2010

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