PM&R
Volume 2, Issue 5 , Pages 332-337, May 2010

Central Fatigue: Issues Related to Cognition, Mood and Behavior, and Psychiatric Diagnoses

  • Victoria M. Leavitt, PhD

      Affiliations

    • Neuropsychology and Neuroscience Laboratory, Kessler Foundation, West Orange, NJ†
    • ,
  • John DeLuca, PhD

      Affiliations

    • Kessler Foundation, 300 Executive Drive, Suite 150, West Orange, NJ 07052‡
    • Corresponding Author InformationAddress correspondence to: J.D.L.

Received 19 January 2010; accepted 21 March 2010.

Abstract

Describe and define the concept of central fatigue, as well as discuss the behavioral and neuroimaging studies that attempt its assessment and measurement. A brief description of how fatigue can be differentiated from psychiatric symptoms and from sleepiness is also provided. Promising directions for future research will be outlined in the final portion of this review. Despite its popular clinical use as a descriptor of certain symptomatology, fatigue is not a unitary construct. Describing central fatigue as distinct from peripheral fatigue represents one way of understanding the underlying neural and behavioral concomitants of fatigue.

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  • † Disclosure: nothing to disclose
  • ‡ Disclosure: Funded in part by grant MB 0003 from the National Multiple Sclerosis Society, to JD

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(10)00295-9

doi:10.1016/j.pmrj.2010.03.027

PM&R
Volume 2, Issue 5 , Pages 332-337, May 2010

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