PM&R
Volume 2, Issue 5 , Pages 384-392 , May 2010

Fatigue in Systemic Lupus Erythematosus and Rheumatoid Arthritis

  • Rosalind Ramsey-Goldman, MD, DrPH

      Affiliations

    • Department of Medicine, 240 E. Huron, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611†
    • Corresponding Author InformationAddress correspondence to: R.R.-G.
    • ,
  • Nan Rothrock, PhD

      Affiliations

    • Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL‡

Received 23 December 2009 ,Accepted 21 March 2010.

References 

  1. Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med. 2008;358:929–939
  2. Gordon C, Ramsey-Goldman R. Systemic lupus eruthematosus and lupus-like syndromes. In:  Adebajo A editors. ABC of Rheumatology. 4th ed.. Chichester, UK: Wiley-Blackwell; 2009;
  3. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271–1277
  4. Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725
  5. Krupp LB, LaRocca NG, Muir J, Steinberg AD. A study of fatigue in systemic lupus erythematosus. J Rheumatol. 1990;17(11):1450–1452
  6. Tench CM, McCurdie I, White PD, D'Cruz DP. The prevalence and associations of fatigue in systemic lupus erythematosus. Rheumatology (Oxford). 2000;39:1249–1254
  7. Zonana-Nacach A, Roseman JM, McGwin G, Friedman AW, Baethge BA, Reveille JD. Systemic lupus erythematosus in three ethnic groups (VI: Factors associated with fatigue within 5 years of criteria diagnosis). Lupus. 2000;9:101–109
  8. Burgos PI, Alarcon GS, McGwin G, Crews KQ, Reveille JD, Vila LM. Disease activity and damage are not associated with increased levels of fatigue in systemic lupus erythematosus patients from a multiethnic cohort: LXVII. Arthritis Rheum. 2009;61:1179–1186
  9. National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases. The Future Directions of Lupus Research. 2007. http://www.niams.nih.gov/About_Us/Mission_and_Purpose/lupus_plan.pdfAccessed December 17, 2009
  10. Al Dhanhani AM, Gignac MA, Su J, Fortin PR. Work disability in systemic lupus erythematosus. Arthritis Rheum. 2009;61:378–385
  11. Panopalis P, Yazdany J, Gillis JZ, et al. Health care costs and costs associated with changes in work productivity among persons with systemic lupus erythematosus. Arthritis Care Res. 2008;59:1788–1795
  12. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale (Application to patients with multiple sclerosis and systemic lupus erythematosus). Arch Neurol. 1989;46:1121–1123
  13. Robb-Nicholson LC, Daltroy L, Eaton H, et al. Effects of aerobic conditioning in lupus fatigue: a pilot study. Rheumatology. 1989;28:500–505
  14. Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res. 1993;37:147–153
  15. Schwartz JE, Jandorg L, Krupp LB. The measurement of fatigue: A new instrument. J Psychosom Res. 1993;17:762
  16. Taylor J, Skan J, Erb N, et al. Lupus patients with fatigue–is there a link with fibromyalgia syndrome?. Rheumatology. 2000;39:620–623
  17. Stoll T, Gordon C, Seifert B, et al. Consistency and validity of patient administered assessment of quality of life by the MOS SF-36: Its association with disease activity and damage in patients with systemic lupus erythematosus. J Rheumatol. 1997;24:1608–1614
  18. Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue. Measurement of fatigue in systemic lupus erythematosus: A systematic review. Arthritis Care Res. 2007;57:1348–1357
  19. Goligher EC, Pouchot J, Brant R, et al. Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus. J Rheumatol. 2008;35:635–642
  20. Lai JS, Cella D, Choi S, Teresi JA, Hays RD, Stone AA. Developing a fatigue item bank for the Patient-Reported Outcomes Measurement Information System (PROMIS FIB version 1). Presented at the Meeting of the Survey Methods in Multicultural, Multinational, and Multiregional Contexts (3MC), Berlin, Germany; 2008.
  21. Lai JS, Beaumont JL, Cella D, Brunetta P, Ogale S. Validation of the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale in patients with systemic lupus erythematosus (SLE). Paper presented at: ISPOR 12th Annual European Congress; 2009; Paris, France.
  22. Cella D, Yount S, Rothrock N, et al. The Patient-Reported Outcomes Measurement Information System (PROMIS): Progress of an NIH Roadmap Cooperative Group During its First Two Years. Med Care. 2007;45(5 Suppl 1):S3–S11
  23. Harboe E, Greve OJ, Beyer M, et al. Fatigue is associated with cerebral white matter hyperintensities in patients with systemic lupus erythematosus. J Neurol Neurosurg Psychiatry. 2008;79:199–201
  24. Omdal R, Mellgren SI, Koldingsnes W, Jacobsen EA, Husby G. Fatigue in patients with systemic lupus erythematosus: Lack of associations to serum cytokines, antiphospholipid antibodies, or other disease characteristics. J Rheumatol. 2002;29:482–486
  25. Omdal R, Sjöholm H, Koldingsnes W, et al. Fatigue in patients with lupus is not associated with disturbances in cerebral blood flow as detected by SPECT. J Neurol. 2005;252:78–83
  26. Ramsey-Goldman R, Schilling EM, Dunlop D, et al. A pilot study on the effects of exercise in patients with systemic lupus erythematosus. Arthritis Care Res. 2000;13:262–269
  27. Carvalho MR, Sato EI, Tebexreni AS, Heidecher RT, Schenkman S, Neto TL. Effects of supervised cardiovascular training program on exercise tolerance, aerobic capacity, and quality of life in patients with systemic lupus erythematosus. Arthritis Rheum. 2005;53:838–844
  28. Tench C, Bentley D, Vleck V, McCurdie I, White P, D'Cruz D. Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. J Rheumatol. 2002;29:474–481
  29. Campillo B, Fouet P, Bonnet JC, Atlan G. Submaximal oxygen consumption in liver cirrhosis (Evidence of severe functional aerobic impairment). J Hepatol. 1990;10:163–167
  30. Zdrenghea D, Giurgea N, Predescu D, Timis D, Icusca G. Exercise testing in patients with valvular diseases. Rom J Intern Med. 1994;32:23–28
  31. Keyser RE, Rus V, Cade WT, Kalappa N, Flores RH, Handwerger BS. Evidence for aerobic insufficiency in women with systemic lupus erythematosus. Arthritis Care Res. 2003;49:16–22
  32. Bostrom C, Dupre B, Tengvar P, Jansson E, Opava C, Lundberg I. Aerobic capacity correlates to self-assessed physical function but not to overall disease activity or organ damage in women with systemic lupus erythematosus with low-to-moderate disease activity and organ damage. Lupus. 2008;17:100–104
  33. Costa DD, Bernatsky S, Dritsa M, et al. Determinants of sleep quality in women with systemic lupus erythematosus. Arthritis Rheum. 2005;53:272–278
  34. McKinley PS, Ouellette SC, Winkel GH. The contributions of disease activity, sleep patterns, and depression to fatigue in systemic lupus erythematosus. Arthritis Rheum. 1995;38:826–834
  35. Valencia-Flores M, Resendiz M, Castãno VA, et al. Objective and subjective sleep disturbances in patients with systemic lupus erythematosus. Arthritis Rheum. 1999;42:2189–2193
  36. Gudbjornsson B, Hetta J. Sleep disturbances in patients with systemic lupus erythematosus: a questionnaire-based study. Clin Exp Rheumatol. 2001;19:509–514
  37. Greenwood KM, Lederman L, Lindner HD. Self-reported sleep in systemic lupus erythematosus. Clin Rheumatol. 2008;27:1147–1151
  38. Iaboni A, Ibanez D, Gladman DD, Urowitz MB, Moldofsky H. Fatigue in systemic lupus erythematosus: contributions of disordered sleep, sleepiness, and depression. J Rheumatol. 2006;33:2453–2457
  39. Ranjbaran Z, Keefer L, Stepanski E, Farhadi A, Keshavarzian A. The relevance of sleep abnormalities to chronic inflammatory conditions. Inflamm Res. 2007;56:51–57
  40. Brey RL, Holliday SL, Saklad AR, et al. Neuropsychiatric syndromes in lupus: Prevalence using standardized definitions. Neurology. 2002;58:1214–1220
  41. Ayan C, Martin V. Systemic lupus erythematosus and exercise. Lupus. 2007;16:5–9
  42. Daltroy LH, Robb-Nicholson C, Iversen MD, Wright EA, Liang MH. Effectiveness of minimally supervised home aerobic training in patients with systemic rheumatic disease. Br J Rheumatol. 1995;34:1064–1069
  43. Tench CM, McCarthy J, McCurdie I, White PD, D'Cruz DP. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise. Rheumatology. 2003;42:1050–1054
  44. Jump RL, Robinson ME, Armstrong AE, Barnes EV, Kilbourn KM, Richards HB. Fatigue in systemic lupus erythematosus: contributions of disease activity, pain, depression, and perceived social support. J Rheumatol. 2005;32:1699–1705
  45. Wang B, Gladman DD, Urowitz MB. Fatigue in lupus is not correlated with disease activity. J Rheumatol Suppl. 1998;25:892–894
  46. Da Costa D, Dritsa M, Bernatsky S, et al. Dimensions of fatigue in systemic lupus erythematosus: Relationship to disease status and behavioral and psychosocial factors. J Rheumatol. 2006;33:1282–1288
  47. Fortin PR, Abrahamowicz M, Neville C, et al. Impact of disease activity and cumulative damage on the health of lupus patients. Lupus. 1998;7:101–107
  48. Wang C, Mayo NE, Fortin PR. The relationship between health related quality of life and disease activity and damage in systemic lupus erythematosus. J Rheumatol. 2001;28:525–532
  49. Aaronson LS, Teel CS, Cassmeyer V, et al. Defining and measuring fatigue. Image J Nurs Sch. 1999;31:45–50
  50. Kozora E, West SG, Kotzin BL, Julian L, Porter S, Bigler E. Magnetic resonance imaging abnormalities and cognitive deficits in systemic lupus erythematosus patients without overt central nervous system disease. Arthritis Rheum. 1998;41:41–47
  51. Denburg SD, Carbotte RM, Ginsberg JS, Denburg JA. The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus. J Int Neuropsychol Soc. 1997;3:377–386
  52. Denburg SD, Carbotte RM, Denburg JA. Cognitive impairment in systemic lupus erythematosus: A neuropsychological study of individual and group deficits. J Clin Exp Neuropsychol. 1987;9:323–339
  53. Mikdashi JA. Proposed response criteria for neurocognitive impairment in systemic lupus erythematosus clinical trials. Lupus. 2007;16:418–425
  54. Marsland AL, Petersen KL, Sathanoori R, et al. Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers. Psychosom Med. 2006;68:895–903
  55. Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus. Arthritis Rheum. 2006;54:2550–2557
  56. Omdal R, Waterloo K, Koldingsnes W, Husby G, Mellgren SI. Fatigue in patients with systemic lupus erythematosus: The psychosocial aspects. J Rheumatol. 2003;30:283–287
  57. Greco C, Kao A, Maksimowicz-McKinnon K, et al. Acupuncture for systemic lupus erythematosus: A pilot RCT feasibility and safety study. Lupus. 2008;17:1108–1116
  58. Meenan RF, Gertman PM, Mason JH. Measuring health status in arthritis: The Arthritis Impact Measurment Scales. Arthritis Rheum. 1980;23:142–152
  59. Meenan RF, Mason JH, Anderson JJ, Guccione AA, Kazis LE. AIMS2 (The content and properties of a revised and expanded Arthritis Impact Measurement Scales Health Status Questionnaire). Arthritis Rheum. 1992;35:1–10
  60. Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36) (I. Conceptual Framework and Item Selection). Med Care. 1992;30:473–483
  61. Karlson EW, Liang MH, Eaton A, Huang J, Fitzgerald L, Rogers MD, et al. A randomized clinical trial of psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum. 2004;50:1832–1841
  62. Goodenow C, Reisine ST, Grady KE. Quality of social support and associated social and psychological functioning in women with rheumatoid arthritis. Health Psychol. 1990;9:266–284
  63. Karlson EW, Daltroy LH, Rivest C, et al. Validation of a systemic lupus activity questionnaire (SLAQ) for population studies. Lupus. 2003;12:280–286
  64. Hartkamp A, Geenen R, Godaert GLR, Bijl M, Bijlsma JWJ, Derksen RHWM. Effects of dehydroepiandrosterone on fatigue and well-being in women with quiescent systemic lupus erythematosus (A randomized controlled trial). Ann Rheum Dis. 2010;In press
  65. Smets EMA, Garssen B, Bonke B, DeHaes JCJM. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315–325
  66. Cella D, Yount S, Sorensen M, Chartash E, Sengupta N, Grober J. Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis. J Rheumatol. 2005;32:811–819
  67. Navarra S, Guzman R, Gallacher A, et al. Belimumab, a BLyS-specific inhibitor, reduced disease activity, flares and prednisone use in patients with active SLE: Efficacy and safety results from the Phase 3 BLISS-52 Study. Arthritis Rheum. 2009;60(October 2009 Abstract Suppl):3860
  68. Banal F, Dougados M, Combescure C, Gossec L. Sensitivity and specificity of the American College of Rheumatology 1987 criteria for the diagnosis of rheumatoid arthritis according to disease duration: A systematic literature review and meta-analysis. Ann Rheum Dis. 2009;68:1184–1191
  69. Lawrence RC, Helmich CG, Arnett FC, et al. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum. 1998;41:778–799
  70. Arnett FC, Edworthy SM, Bloch DA, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315–324
  71. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum. 2002;46:328–346
  72. Wolfe F, Hawley DJ. Measurement of the quality of life in rheumatic disorders using the EuroQol. Br J Rheumatol. 1997;36:786–793
  73. Listing J, Strangfeld A, Rau R, et al. Clinical and functional remission: even though biologics are superior to conventional DMARDs overall success rates remain low–results from RABBIT, the German biologics register. Arthritis Res Ther. 2006;8:R66
  74. Lillegraven S, Kvien TK. Measuring disability and quality of life in established rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:827–840
  75. Hewlett S, Hehir M, Kirwan JR. Measuring fatigue in rheumatoid arthritis: A systematic review of scales in use. Arthritis Care Res. 2007;57:429–439
  76. Pouchot J, Kherani RB, Brant R, et al. Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis. J Clin Epidemiol. 2008;61:705–713
  77. Repping-Wuts H, Hewlett S, Riel PV, Achterberg TV. Fatigue in patients with rheumatoid arthritis: British and Dutch nurses' knowledge, attitudes and management. J Adv Nurs. 2009;65:901–911
  78. Wolfe F, Hawley DJ, Wilson K. The prevalence and meaning of fatigue in rheumatic disease. J Rheumatol. 1996;23:1407–1417
  79. Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology. 2006;45:885–889
  80. Belza BL, Henke CJ, Yelin EH, Epstein WV, Gilliss CL. Correlates of fatigue in older adults with rheumatoid arthritis. Nurs Res. 1993;42:93–99
  81. Pinals RS, Masi AT, Larsen RA. Preliminary criteria for clinical remission in rheumatoid arthritis. Arthritis Rheum. 1981;24:1308–1315
  82. Kosinski M, Kujawski SC, Martin R, et al. Health-related quality of life in early rheumatoid arthritis: Impact of disease and treatment response. Am J Manag Care. 2002;8:231–240
  83. Yount S, Sorensen MV, Cella D, Sengupta N, Grober J, Chartash EK. Adalimumab plus methotrexate or standard therapy is more effective than methotrexate or standard therapies alone in the treatment of fatigue in patients with active, inadequately treated rheumatoid arthritis. Clin Exp Rheumatol. 2007;25:838–846
  84. Hewlett S, Cockshott Z, Byron M, et al. Patients' perceptions of fatigue in rheumatoid arthritis: Overwhelming, uncontrollable, ignored. Arthritis Care Res. 2005;53:697–702
  85. Stone AA, Broderick JE, Porter LS, Kaell AT. The experience of rheumatoid arthritis pain and fatigue: examining momentary reports and correlates over one week. Arthritis Care Res. 1997;10:185–193
  86. Mancuso CA, Rincon M, Sayles W, Paget SA. Psychosocial variables and fatigue: A longitudinal study comparing individuals with rheumatoid arthritis and healthy controls. J Rheumatol. 2006;33:1496–1502
  87. Hewlett SA. Patients and clinicians have different perspectives on outcomes in arthritis. J Rheumatol. 2003;30:877–879
  88. Repping-Wuts H, van Riel P, van Achterberg T. Rheumatologists' knowledge, attitude and current management of fatigue in patients with rheumatoid arthritis (RA). Clin Rheumatol. 2008;27:1549–1555
  89. Wolfe F, Michaud K. Fatigue, rheumatoid arthritis, and anti-tumor necrosis factor therapy: an investigation in 24,831 patients. J Rheumatol. 2004;31:2115–2120
  90. Kirwan JR, Hewlett S. Patient perspective: Reasons and methods for measuring fatigue in rheumatoid arthritis. J Rheumatol. 2007;34:1171–1173
  91. Kirwan JR, Minnock P, Adebajo A, et al. Patient perspective: Fatigue as a recommended patient centered outcome measure in rheumatoid arthritis. J Rheumatol. 2007;34:1174–1177
  92. Heller JE, Shadick NA. Outcomes in rheumatoid arthritis: Incorporating the patient perspective. Curr Opin Rheumatol. 2007;19:101–105
  93. Methiniti D, Coulson E, Kelly C. Fatigue in rheumatoid arthritis. Rheumatology. 2009;48:1166–1180
  94. Wilson A, Yu H-T, Goodnough LT, Nissenson AR. Prevalence and outcomes of anemia in rheumatoid arthritis: A systematic review of the literature. Am J Med. 2004;116(Suppl 1):50–57
  95. Bergman MJ, Shahouri SS, Shaver TS, et al. Is fatigue an inflammatory variable in rheumatoid arthritis (RA)? (Analyses of fatigue in RA, osteoarthritis, and fibromyalgia). J Rheumatol. 2009;36:2788–2794
  96. Capellino S, Straub RH. Neuroendocrine immune pathways in chronic arthritis. Best Pract Res Clin Rheumatol. 2008;22:285–297
  97. Repping-Wuts H, van Riel P, van Achterberg T. Fatigue in patients with rheumatoid arthritis: What is known and what is needed. Rheumatology. 2009;48:207–209
  98. Huyser BA, Parker JC, Thoreson R, Smarr KL, Johnson JC, Hoffman R. Predictors of subjective fatigue among individuals with rheumatoid arthritis. Arthritis Rheum. 1998;41:2230–2237
  99. Fifield J, McQuillan J, Tennen H, et al. History of affective disorder and the temporal trajectory of fatigue in rheumatoid arthritis. Ann Behav Med. 2001;23:34–41
  100. Kalyoncu U, Dougados M, Daures J-P, Gossec L. Reporting of patient-reported outcomes in recent trials in rheumatoid arthritis: A systematic literature review. Ann Rheum Dis. 2009;68:183–190
  101. Mäkinen H, Hannonen P, Sokka T. Definitions of remission for rheumatoid arthritis and review of selected clinical cohorts and randomised clinical trials for the rate of remission. Clin Exp Rheumatol. 2006;24(Suppl 43):S22–S28
  102. Saag KG, Teng GG, Patkar NM, et al. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008;59:762–784
  103. Russell AS. Quality-of-life assessment in rheumatoid arthritis. Pharmacoeconomics. 2008;26:831–846
  104. Strand V, Scott DL, Emery P, et al. Physical function and health related quality of life: analysis of 2-year data from randomized, controlled studies of leflunomide, sulfasalazine, or methotrexate in patients with active rheumatoid arthritis. J Rheumatol. 2005;32:590–601
  105. Strand V, Singh JA. Improved health-related quality of life with effective disease-modifying antirheumatic drugs: Evidence from randomized controlled trials. Am J Manag Care. 2008;14:234–254
  106. Moreland LW, Genovese MC, Sato R, Singh A. Effect of etanercept on fatigue in patients with recent or established rheumatoid arthritis. Arthritis Care Res. 2006;55:287–293
  107. Neill J, Belan I, Ried K. Effectiveness of non-pharmacological interventions for fatigue in adults with multiple sclerosis, rheumatoid arthritis, or systemic lupus erythematosus: A systematic review. J Adv Nurs. 2006;56:617–635
  108. Evers AW, Kraaimaat FW, van Riel PL, de Jong AJ. Tailored cognitive-behavioral therapy in early rheumatoid arthritis for patients at risk: A randomized controlled trial. Pain. 2002;100:141–153
  109. National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases. Draft long-range plan for 2010-2014. 2009. http://www.niams.nih.gov/About_Us/Mission_and_Purpose/draft_long_range_plan.aspAccessed December 22, 2009
  110. Ader DN. Developing the Patient-Reported Outcomes Measurement Information System (PROMIS). Med Care. 2007;45(Suppl 1):S1–S2

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PII: S1934-1482(10)00294-7

doi: 10.1016/j.pmrj.2010.03.026

PM&R
Volume 2, Issue 5 , Pages 384-392 , May 2010

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