PM&R
Volume 2, Issue 5 , Pages 364-383 , May 2010

Cancer-Related Fatigue: State of the Science

Received 14 December 2009 ,Accepted 21 March 2010.

References 

  1. Cella D, Peterman A, Passik S, Jacobsen P, Breitbart W. Progress toward guidelines for the management of fatigue. Oncology. 1998;12:369–377
  2. Curt G. Impact of fatigue on quality of life in oncology patients. Semin Hematol. 2000;37(4 Suppl 6):14–17
  3. Mallinson T, Cella D, Cashy J, Holzner B. Giving meaning to measure: Linking self-reported fatigue and function to performance of everyday activities. J Pain Symptom Manage. 2006;31:229–241
  4. Curt G, Johnston PG. Cancer fatigue: The way forward. Oncologist. 2003;8(Suppl 1):27–30
  5. de Jong N, Candel MJ, Schouten HC, Abu-Saad HH, Courtens AM. Course of the fatigue dimension “activity level” and the interference of fatigue with daily living activities for patients with breast cancer receiving adjuvant chemotherapy. Cancer Nurs. 2006;29:E1–E13
  6. Dimeo F, Schmittel A, Fietz T, et al. Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment. Ann Oncol. 2004;15:1237–1242
  7. Andrykowski MA, Curran SL, Lightner R. Off-treatment fatigue in breast cancer survivors: A controlled comparison. J Behav Med. 1998;21:1–18
  8. Lindqvist O, Widmark A, Rasmussen BH. Meanings of the phenomenon of fatigue as narrated by 4 patients with cancer in palliative care. Cancer Nurs. 2004;27:237–243
  9. Magnusson K, Moller A, Ekman T, Wallgren A. A qualitative study to explore the experience of fatigue in cancer patients. Eur J Cancer Care (Engl). 1999;8:224–232
  10. Rao AV, Cohen HJ. Fatigue in older cancer patients: Etiology, assessment, and treatment. Semin Oncol. 2008;35:633–642
  11. Servaes P, Verhagen S, Bleijenberg G. Determinants of chronic fatigue in disease-free breast cancer patients: A cross-sectional study. Ann Oncol. 2002;13:589–598
  12. Wang XS, Giralt SA, Mendoza TR, et al. Clinical factors associated with cancer-related fatigue in patients being treated for leukemia and non-Hodgkin's lymphoma. J Clin Oncol. 2002;20:1319–1328
  13. Mystakidou K, Parpa E, Katsouda E, Galanos A, Vlahos L. The role of physical and psychological symptoms in desire for death: A study of terminally ill cancer patients. Psychooncology. 2006;15:355–360
  14. Hockenberry-Eaton M, Hinds PS. Fatigue in children and adolescents with cancer: Evolution of a program of study. Semin Oncol Nurs. 2000;16:261–272discussion 272-278
  15. Vogelzang NJ, Breitbart W, Cella D, et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: Results of a tripart assessment survey. The Fatigue Coalition. Semin Hematol. 1997;34(3 Suppl 2):4–12
  16. Knowles G, Borthwick D, McNamara S, Miller M, Leggot L. Survey of nurses' assessment of cancer-related fatigue. Eur J Cancer Care (Engl). 2000;9:105–113
  17. Shun SC, Lai YH, Hsiao FH. Patient-related barriers to fatigue communication in cancer patients receiving active treatment. Oncologist. 2009;14:936–943
  18. Collins S, de Vogel-Voogt E, Visser A, van der Heide A. Presence, communication and treatment of fatigue and pain complaints in incurable cancer patients. Patient Educ Couns. 2008;72:102–108
  19. Passik SD, Kirsh KL, Donaghy K, et al. Patient-related barriers to fatigue communication: Initial validation of the fatigue management barriers questionnaire. J Pain Symptom Manage. 2002;24:481–493
  20. Cancer-related fatigue (version 1.2010) (National Comprehensive Cancer Network). http://www.nccn.org/professionals/physician_gls/PDF/fatigue.pdf2010;Accessed January 2, 2010
  21. Cella D, Lai JS, Chang CH, Peterman A, Slavin M. Fatigue in cancer patients compared with fatigue in the general United States population. Cancer. 2002;94:528–538
  22. Glaus A, Crow R, Hammond S. A qualitative study to explore the concept of fatigue/tiredness in cancer patients and in healthy individuals. Eur J Cancer Care. 1996;5(2 Suppl):8–23
  23. Wu HS, McSweeney M. Cancer-related fatigue: “It's so much more than just being tired.”. Eur J Oncol Nurs. 2007;11:117–125
  24. Andrykowski MA, Schmidt JE, Salsman JM, Beacham AO, Jacobsen PB. Use of a case definition approach to identify cancer-related fatigue in women undergoing adjuvant therapy for breast cancer. J Clin Oncol. 2005;23:6613–6622
  25. Yavuzsen T, Davis MP, Ranganathan VK, et al. Cancer-related fatigue: Central or peripheral?. J Pain Symptom Manage. 2009;38:587–596
  26. Sadler IJ, Jacobsen PB, Booth-Jones M, Belanger H, Weitzner MA, Fields KK. Preliminary evaluation of a clinical syndrome approach to assessing cancer-related fatigue. J Pain Symptom Manage. 2002;23:406–416
  27. Tchekmedyian NS, Kallich J, McDermott A, Fayers P, Erder MH. The relationship between psychologic distress and cancer-related fatigue. Cancer. 2003;98:198–203
  28. Jacobsen PB, Donovan KA, Weitzner MA. Distinguishing fatigue and depression in patients with cancer. Semin Clin Neuropsychiatry. 2003;8:229–240
  29. Capuron L, Gumnick JF, Musselman DL, et al. Neurobehavioral effects of interferon-alpha in cancer patients: Phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology. 2002;26:643–652
  30. Reuter K, Harter M. The concepts of fatigue and depression in cancer. Eur J Cancer Care (Engl). 2004;13:127–134
  31. Van Belle S, Paridaens R, Evers G, et al. Comparison of proposed diagnostic criteria with FACT-F and VAS for cancer-related fatigue: Proposal for use as a screening tool. Support Care Cancer. 2005;13:246–254
  32. Hinshaw DB, Carnahan JM, Johnson DL. Depression, anxiety, and asthenia in advanced illness. J Am Coll Surg. 2002;195(2):271–277
  33. Valentine AD, Meyers CA. Cognitive and mood disturbance as causes and symptoms of fatigue in cancer patients. Cancer. 2001;92(6 Suppl):1694–1698
  34. Lai J-S, Cella D, Dineen K, et al. An item bank was created to improve the measurement of cancer-related fatigue. J Clin Epidemiol. 2005;58(2):190–197
  35. Lee BN, Dantzer R, Langley KE, et al. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation. 2004;11(5):279–292
  36. Bower JE, Ganz PA, Aziz N. Altered cortisol response to psychologic stress in breast cancer survivors with persistent fatigue. Psychosom Med. 2005;67:277–280
  37. Ahlberg K, Ekman T, Gaston-Johansson F, Mock V. Assessment and management of cancer-related fatigue in adults. Lancet. 2003;362:640–650
  38. Prue G, Rankin J, Allen J, Gracey J, Cramp F. Cancer-related fatigue: A critical appraisal. Eur J Cancer. 2006;42:846–863
  39. Kuhnt S, Ernst J, Singer S, et al. Fatigue in cancer survivors—prevalence and correlates. Onkologie. 2009;32:312–317
  40. Servaes P, Verhagen C, Bleijenberg G. Fatigue in cancer patients during and after treatment: Prevalence, correlates and interventions. Eur J Cancer. 2002;38:27–43
  41. Butt Z, Rosenbloom SK, Abernethy AP, et al. Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy. J Natl Compr Canc Netw. 2008;6:448–455
  42. Bower JE, Ganz PA, Desmond KA, et al. Fatigue in long-term breast carcinoma survivors: A longitudinal investigation. Cancer. 2006;106(4):751–758
  43. Andrykowski MA, Carpenter JS, Greiner CB, et al. Energy level and sleep quality following bone marrow transplantation. Bone Marrow Transplant. 1997;20:669–679
  44. Young KE, White CA. The prevalence and moderators of fatigue in people who have been successfully treated for cancer. J Psychosom Res. 2006;60:29–38
  45. Hjermstad MJ, Oldervoll L, Fossa SD, Holte H, Jacobsen AB, Loge JH. Quality of life in long-term Hodgkin's disease survivors with chronic fatigue. Eur J Cancer. 2006;42:327–333
  46. Johnsen A, Petersen M, Pedersen L, Groenvold M. Symptoms and problems in a nationally representative sample of advanced cancer patients. Palliat Med. 2009;23:491–501
  47. Glaus A, Boehme C, Thurlimann B, et al. Fatigue and menopausal symptoms in women with breast cancer undergoing hormonal cancer treatment. Ann Oncol. 2006;17:801–806
  48. Beck SL, Dudley WN, Barsevick A. Pain, sleep disturbance, and fatigue in patients with cancer: Using a mediation model to test a symptom cluster. Oncol Nurs Forum. 2005;32:542
  49. Bender CM, Ergyn FS, Rosenzweig MQ, Cohen SM, Sereika SM. Symptom clusters in breast cancer across 3 phases of the disease. Cancer Nurs. 2005;28:219–225
  50. Chow E, Fan G, Hadi S, Filipczak L. Symptom clusters in cancer patients with bone metastases. Support Care Cancer 30. 2007;15:1035–1043
  51. Francoeur RB. The relationship of cancer symptom clusters to depressive affect in the initial phase of palliative radiation. J Pain Symptom Manage. 2005;29:130–155
  52. Walsh D, Rybicki L. Symptom clustering in advanced cancer. Support Care Cancer. 2006;14:831–836
  53. al-Majid S, McCarthy DO. Cancer-induced fatigue and skeletal muscle wasting: The role of exercise. Biol Res Nurs. 2001;2:186–197
  54. Wagner LI, Cella D. Fatigue and cancer: Causes, prevalence and treatment approaches. Br J Cancer. 2004;91:822–828
  55. Stasi R, Abriani L, Beccaglia P, Terzoli E, Amadori S. Cancer-related fatigue: Evolving concepts in evaluation and treatment. Cancer. 2003;98:1786–1801
  56. Iop A, Manfredi AM, Bonura S. Fatigue in cancer patients receiving chemotherapy: An analysis of published studies. Ann Oncol. 2004;15:712–720
  57. Morrow GR, Shelke AR, Roscoe JA, Hickok JT, Mustian K. Management of cancer-related fatigue. Cancer Invest. 2005;23:229–239
  58. Tavio M, Milan I, Tirelli U. Cancer-related fatigue. (review) Int J Oncol. 2002;21:1093–1099
  59. Nail LM. Fatigue in patients with cancer. Oncol Nurs Forum. 2002;29:537
  60. Nail LM. My get up and go got up and went: Fatigue in people with cancer. J Natl Cancer Inst Monogr. 2004;72–75
  61. Strasser F, Palmer JL, Schover LR, et al. The impact of hypogonadism and autonomic dysfunction on fatigue, emotional function, and sexual desire in male patients with advanced cancer: A pilot study. Cancer. 2006;107:2949–2957
  62. Paddison JS, Temel JS, Fricchione GL, Pirl WF. Using the differential from complete blood counts as a biomarker of fatigue in advanced non-small-cell lung cancer: An exploratory analysis. Palliat Support Care. 2009;7:213–217
  63. Sateia MJ, Lang BJ. Sleep and cancer: Recent developments. Curr Oncol Rep. 2008;10:309–318
  64. Ray M, Rogers LQ, Trammell RA, Toth LA. Fatigue and sleep during cancer and chemotherapy: Translational rodent models. Comp Med. 2008;58:234–245
  65. Jones LW, Eves ND, Haykowsky M, Freedland SJ, Mackey JR. Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol. 2009;10:598–605
  66. Capuano G, Gentile PC, Bianciardi F, Tosti M, Palladino A, Di Palma M. Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer before treatment. Support Care Cancer. 2009;18:433–437
  67. Bower JE. Cancer-related fatigue: Links with inflammation in cancer patients and survivors. Brain Behav Immun. 2007;21:863–871
  68. Collado-Hidalgo A, Bower JE, Ganz PA, Cole SW, Irwin MR. Inflammatory biomarkers for persistent fatigue in breast cancer survivors. Clin Cancer Res. 2006;12:2759–2766
  69. Schubert C, Hong S, Natarajan L, Mills PJ, Dimsdale JE. The association between fatigue and inflammatory marker levels in cancer patients: A quantitative review. Brain Behav Immun. 2007;21:413–427
  70. Wood LJ, Nail LM, Gilster A, Winters KA, Elsea CR. Cancer chemotherapy-related symptoms: Evidence to suggest a role for proinflammatory cytokines. Oncol Nurs Forum. 2006;33:535–542
  71. Ancoli-Israel S, Liu L, Marler MR, et al. Fatigue, sleep, and circadian rhythms prior to chemotherapy for breast cancer. Support Care Cancer. 2006;14:201–209
  72. Bower JE, Ganz PA, Dickerson SS, Petersen L, Aziz N, Fahey JL. Diurnal cortisol rhythm and fatigue in breast cancer survivors. Psychoneuroendocrinology. 2005;30:92–100
  73. Massacesi C, Terrazzino S, Marcucci F, et al. Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy. Cancer. 2006;106:1007–1016
  74. Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008;26:971–982
  75. Ryan JL, Carroll JK, Ryan EP, Mustian KM, Fiscella K, Morrow GR. Mechanisms of cancer-related fatigue. Oncologist. 2007;12(Suppl 1):22–34
  76. Kumari M, Badrick E, Chandola T, et al. Cortisol secretion and fatigue: Associations in a community based cohort. Psychoneuroendocrinology. 2009;34:1476–1485
  77. Hrushesky WJ, Grutsch JF, Wood P, et al. Circadian clock manipulation for cancer prevention and control and the relief of cancer symptoms. Integr Cancer Ther. 2009;8:387–397
  78. Bower JE, Ganz PA, Tao ML, et al. Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer. Clin Cancer Res. 2009;15:5534–5540
  79. Basen-Engquist K, Scruggs S, Jhingran A, et al. Physical activity and obesity in endometrial cancer survivors: Associations with pain, fatigue, and physical functioning. Am J Obstet Gynecol. 2009;200:288;e281-288
  80. Cerchietti LC, Navigante AH, Castro MA. Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. Nutr Cancer. 2007;59:14–20
  81. Berger AM, Farr LA, Kuhn BR, Fischer P, Agrawal S. Values of sleep/wake, activity/rest, circadian rhythms, and fatigue prior to adjuvant breast cancer chemotherapy. J Pain Symptom Manage. 2007;33:398–409
  82. Fernandes R, Stone P, Andrews P, Morgan R, Sharma S. Comparison between fatigue, sleep disturbance, and circadian rhythm in cancer inpatients and healthy volunteers: Evaluation of diagnostic criteria for cancer-related fatigue. J Pain Symptom Manage. 2006;32:245–254
  83. Collado-Hidalgo A, Bower JE, Ganz PA, Irwin MR, Cole SW. Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings. Brain Behav Immun. 2008;22:1197–1200
  84. Jager A, Sleijfer S, van der Rijt CC. The pathogenesis of cancer related fatigue: Could increased activity of pro-inflammatory cytokines be the common denominator?. Eur J Cancer. 2008;44:175–181
  85. Piper B, Lindsey A, Dodd M. Fatigue mechanisms in cancer patients: Developing nursing theory. Oncology Nursing Forum. 1987;14:17–23
  86. Irvine D, Vincent L, Graydon JE, Bubela N, Thompson L. The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy (A comparison with the fatigue experienced by healthy individuals). Cancer Nurs. 1994;17:367–378
  87. Winningham ML. Strategies for managing cancer-related fatigue syndrome: A rehabilitation approach. Cancer 15. 2001;92(4 Suppl):988–997
  88. Andrews P, Morrow GR, Hickok J, Roscoe J, Stone P. Mechanisms and models of fatigue associated with cancer and its treatment: Evidence from preclinical and clinical studies. In:  Armes J,  Krishnasamy M,  Higginson I editor. Fatigue in Cancer. Oxford: Oxford University Press; 2004;p. 51–87
  89. Aistars J. Fatigue in the cancer patient: A conceptual approach to a clinical problem. Oncol Nurs Forum. 1987;14:25–30
  90. Rhoten D. Fatigue and the postsurgical patient. In:  Norris C editors. Conceptual Clarification in Nursing. Rockville, MD: Aspen; 1982;p. 277–300
  91. Glaus A. Fatigue in patients with cancer (Analysis and assessment). Recent Results Cancer Res. 1998;145:I-XI, 1-172
  92. Olson K. A new way of thinking about fatigue: A reconceptualization. Oncology Nursing Forum. 2007;34:93–99
  93. Olson K, Turner AR, Courneya KS, et al. Possible links between behavioral and physiological indices of tiredness, fatigue, and exhaustion in advanced cancer. Support Care Cancer. 2008;16:241–249
  94. Payne JK. A neuroendocrine-based regulatory fatigue model. Biol Res Nurs. 2004;6:141–150
  95. Al-Majid S, Gray DP. A biobehavioral model for the study of exercise interventions in cancer-related fatigue. Biol Res Nurs. 2009;10:381–391
  96. Khoshknabi DS, Davis MP, Ranganathan VK, et al. Combining objective and subjective outcomes in cancer-related fatigue: Illustrations from a single case report. J Palliat Med. 2008;11:829–833
  97. Monga U, Jaweed M, Kerrigan AJ, et al. Neuromuscular fatigue in prostate cancer patients undergoing radiation therapy. Arch Phys Med Rehabil. 1997;78:961–966
  98. Grossman P, Deuring G, Garland SN, Campbell TS, Carlson LE. Patterns of objective physical functioning and perception of mood and fatigue in posttreatment breast cancer patients and healthy controls: An ambulatory psychophysiological investigation. Psychosom Med. 2008;70:819–828
  99. Servaes P, Verhagen C, Bleijenberg G. Relations between fatigue, neuropsychological functioning, and physical activity after treatment for breast carcinoma: Daily self-report and objective behavior. Cancer. 2002;95:2017–2026
  100. Davis KM, Lai JS, Hahn EA, Cella D. Conducting routine fatigue assessments for use in clinical oncology practice: Patient and provider perspectives. Support Care Cancer. 2008;16:379–386
  101. Hwang SS, Chang VT, Kasimis BS. A comparison of three fatigue measures in veterans with cancer. Cancer Invest. 2003;21:363–373
  102. Kirsh KL, Passik S, Holtsclaw E, Donaghy K, Theobald D. I get tired for no reason: A single item screening for cancer-related fatigue. J Pain Symptom Manage. 2001;22:931–937
  103. Temel JS, Pirl WF, Recklitis CJ, Cashavelly B, Lynch TJ. Feasibility and validity of a one-item fatigue screen in a thoracic oncology clinic. J Thorac Oncol. 2006;1:454–459
  104. Danjoux C, Gardner S, Fitch M. Prospective evaluation of fatigue during a course of curative radiotherapy for localised prostate cancer. Support Care Cancer. 2007;15:1169–1176
  105. Butt Z, Wagner LI, Beaumont JL, et al. Use of a single-item screening tool to detect clinically significant fatigue, pain, distress, and anorexia in ambulatory cancer practice. J Pain Symptom Manage. 2008;35:20–30
  106. Butt Z, Wagner LI, Beaumont JL, et al. Longitudinal screening and management of fatigue, pain, and emotional distress associated with cancer therapy. Support Care Cancer. 2008;16:151–159
  107. Strasser F, Muller-Kaser I, Dietrich D. Evaluating cognitive, emotional, and physical fatigue domains in daily practice by single-item questions in patients with advanced cancer: A cross-sectional pragmatic study. J Pain Symptom Manage. 2009;38:505–514
  108. Mark TL, Fortner B, Johnson G. Evaluation of a tablet PC technology to screen and educate oncology patients. Support Care Cancer. 2008;16:371–378
  109. Banthia R, Malcarne VL, Roesch SC, et al. Correspondence between daily and weekly fatigue reports in breast cancer survivors. J Behav Med. 2006;29:269–279
  110. Mota DD, Pimenta CA. Self-report instruments for fatigue assessment: A systematic review. Res Theory Nurs Pract. 2006;20:49–78
  111. Wagner L, Cella D. Cancer related fatigue: Clinical screening, assessment and management. In:  Marty M,  Pecorelli S editor. ESO Scientific Updates: Fatigue, Asthenia, Exhaustion and Cancer. 5th ed.. Oxford, England: Elsevier Science; 2001;p. 201–214
  112. Minton O, Stone P. A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Ann Oncol. 2009;20:17–25
  113. Whitehead L. The measurement of fatigue in chronic illness: A systematic review of unidimensional and multidimensional fatigue measures. J Pain Symptom Manage. 2009;37:107–128
  114. Mendoza TR, Wang XS, Cleeland CS, et al. The rapid assessment of fatigue severity in cancer patients: Use of the Brief Fatigue Inventory. Cancer. 1999;85:1186–1196
  115. Hwang SS, Chang VT, Cogswell J, Kasimis BS. Clinical relevance of fatigue levels in cancer patients at a Veterans Administration Medical Center. Cancer. 2002;94:2481–2489
  116. Chang YJ, Lee JS, Lee CG, et al. Assessment of clinical relevant fatigue level in cancer. Support Care Cancer. 2007;15:891–896
  117. Okuyama T, Tanaka K, Akechi T, et al. Fatigue in ambulatory patients with advanced lung cancer: Prevalence, correlated factors, and screening. J Pain Symptom Manage. 2001;22:554–564
  118. Holley SK. Evaluating patient distress from cancer-related fatigue: An instrument development study. Oncol Nurs Forum. 2000;27:1425–1431
  119. Armes J, Chalder T, Addington-Hall J, Richardson A, Hotopf M. A randomized controlled trial to evaluate the effectiveness of a brief, behaviorally oriented intervention for cancer-related fatigue. Cancer. 2007;110:1385–1395
  120. Alexander S, Minton O, Stone PC. Evaluation of screening instruments for cancer-related fatigue syndrome in breast cancer survivors. J Clin Oncol. 2009;27:1197–1201
  121. Goligher EC, Pouchot J, Brant R, et al. Minimal clinically important difference for 7 measures of fatigue in patients with systemic lupus erythematosus. J Rheumatol. 2008;35:635–642
  122. Pouchot J, Kherani RB, Brant R, et al. Determination of the minimal clinically important difference for seven fatigue measures in rheumatoid arthritis. J Clin Epidemiol. 2008;61(7):705–713
  123. Yellen SB, Cella DF, Webster K, Blendowski C, Kaplan E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997;13(2):63–74
  124. Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;24:547–561
  125. Dittner AJ, Wessely SC, Brown RG. The assessment of fatigue: A practical guide for clinicians and researchers. J Psychosom Res. 2004;56:157–170
  126. Hann DM, Jacobsen PB, Azzarello LM, et al. Measurement of fatigue in cancer patients: Development and validation of the Fatigue Symptom Inventory. Qual Life Res. 1998;7:301–310
  127. Hann DM, Denniston MM, Baker F. Measurement of fatigue in cancer patients: Further validation of the Fatigue Symptom Inventory. Qual Life Res. 2000;9:847–854
  128. Donovan KA, Jacobsen PB, Small BJ, Munster PN, Andrykowski MA. Identifying clinically meaningful fatigue with the Fatigue Symptom Inventory. J Pain Symptom Manage. 2008;36:480–487
  129. Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale (Application to patients with multiple sclerosis and systemic lupus erythematosus). Arch Neurol. 1989;46:1121–1123
  130. Hinds PS, Hockenberry M, Tong X, et al. Validity and reliability of a new instrument to measure cancer-related fatigue in adolescents. J Pain Symptom Manage. 2007;34:607–618
  131. Stein KD, Martin SC, Hann DM, Jacobsen PB. A multidimensional measure of fatigue for use with cancer patients. Cancer Pract. 1998;6:143–152
  132. Stein KD, Jacobsen PB, Blanchard CM, Thors C. Further validation of the multidimensional fatigue symptom inventory-short form. J Pain Symptom Manage. 2004;27:14–23
  133. Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res. 1995;39:315–325
  134. Fillion L, Gelinas C, Simard S, Savard J, Gagnon P. Validation evidence for the French Canadian adaptation of the Multidimensional Fatigue Inventory as a measure of cancer-related fatigue. Cancer Nurs. 2003;26:143–154
  135. Purcell A, Fleming J, Bennett S, Burmeister B, Haines T. Determining the minimal clinically important difference criteria for the Multidimensional Fatigue Inventory in a radiotherapy population. Support Care Cancer. 2010;18:307–315
  136. Belza BL. Comparison of self-reported fatigue in rheumatoid arthritis and controls. J Rheumatol. 1995;22:639–643
  137. Piper BF, Dibble SL, Dodd MJ, Weiss MC, Slaughter RE, Paul SM. The revised Piper Fatigue Scale: Psychometric evaluation in women with breast cancer. Oncol Nurs Forum. 1998;25:677–684
  138. Mota DD, Pimenta CA, Piper BF. Fatigue in Brazilian cancer patients, caregivers, and nursing students: A psychometric validation study of the Piper Fatigue Scale-Revised. Support Care Cancer. 2009;17:645–652
  139. Schneider RA. Reliability and validity of the Multidimensional Fatigue Inventory (MFI-20) and the Rhoten Fatigue Scale among rural cancer outpatients. Cancer Nurs. 1998;21:370–373
  140. Schwartz AL. The Schwartz Cancer Fatigue Scale: Testing reliability and validity. Oncol Nurs Forum. 1998;25:711–717
  141. Schwartz AL, Meek PM, Nail LM, et al. Measurement of fatigue (determining minimally important clinical differences). J Clin Epidemiol. 2002;55:239–244
  142. Lee KA, Hicks G, Nino-Murcia G. Validity and reliability of a scale to assess fatigue. Psychiatry Res. 1991;36:291–298
  143. Meek PM, Nail LM, Barsevick A, et al. Psychometric testing of fatigue instruments for use with cancer patients. Nurs Res. 2000;49:181–190
  144. Schwartz AH. Validity of cancer-related fatigue instruments. Pharmacotherapy. 2002;22:1433–1441
  145. Varricchio CG. Measurement and assessment: What are the issues?. In:  Winingham ML,  Barton-Burke M editor. Fatigue in Cancer: A Multidimensional Approach. Boston: Jones and Bartlett; 2000;p. 55–68
  146. Wu HS, McSweeney M. Measurement of fatigue in people with cancer. Oncol Nurs Forum. 2001;28:1371–1384quiz 1385-1376
  147. Lind L, Karlsson D. A system for symptom assessment in advanced palliative home healthcare using digital pens. Med Inform Internet Med. 2004;29:199–210
  148. Cella D, Gershon R, Lai JS, Choi S. The future of outcomes measurement: Item banking, tailored short-forms, and computerized adaptive assessment. Qual Life Res. 2007;16(Suppl 1):133–141
  149. Jones JB, Snyder CF, Wu AW. Issues in the design of Internet-based systems for collecting patient-reported outcomes. Qual Life Res. 2007;16:1407–1417
  150. Carpenter JS, Rawl S, Porter J, et al. Oncology outpatient and provider responses to a computerized symptom assessment system. Oncol Nurs Forum. 2008;35:661–669
  151. Hacker ED, Ferrans CE. Ecological momentary assessment of fatigue in patients receiving intensive cancer therapy. J Pain Symptom Manage. 2007;33:267–275
  152. Curran SL, Beacham AO, Andrykowski MA. Ecological momentary assessment of fatigue following breast cancer treatment. J Behav Med. 2004;27:425–444
  153. Radbruch L, Strasser F, Elsner F, et al. Fatigue in palliative care patients—an EAPC approach. Palliat Med. 2008;22:13–32
  154. Cheville AL. Cancer-related fatigue. Phys Med Rehabil Clin N Am. 2009;20:405–416
  155. Nourissat A, Vasson MP, Merrouche Y, et al. Relationship between nutritional status and quality of life in patients with cancer. Eur J Cancer. 2008;44:1238–1242
  156. Mitchell S, Beck S, Hood L, Moore K, Tanner E. Putting evidence into practice (PEP): Evidence-based interventions for fatigue during and following cancer and its treatment. Clin J Oncol Nursing. 2007;11:99–113
  157. Kangas M, Bovbjerg DH, Montgomery GH. Cancer-related fatigue: A systematic and meta-analytic review of non-pharmacological therapies for cancer patients. Psychol Bull. 2008;134:700–741
  158. Minton O, Richardson A, Sharpe M, Hotopf M, Stone P. A systematic review and meta-analysis of the pharmacological treatment of cancer-related fatigue. J Natl Cancer Inst. 2008;100:1155–1166
  159. Jacobsen PB, Donovan KA, Vadaparampil ST, Small BJ. Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue. Health Psychol. 2007;26:660–667
  160. Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2008;CD006145
  161. Goedendorp MM, Gielissen MF, Verhagen CA, Bleijenberg G. Psychosocial interventions for reducing fatigue during cancer treatment in adults. Cochrane Database Syst Rev. 2009;CD006953
  162. Agteresch HJ, Dagnelie PC, van der Gaast A, Stijnen T, Wilson JH. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst. 2000;92:321–328
  163. Cullum JL, Wojciechowski AE, Pelletier G, Simpson JS. Bupropion sustained release treatment reduces fatigue in cancer patients. Can J Psychiatry. 2004;49:139–144
  164. Moss EL, Simpson JS, Pelletier G, Forsyth P. An open-label study of the effects of bupropion SR on fatigue, depression and quality of life of mixed-site cancer patients and their partners. Psychooncology. 2006;15:259–267
  165. Bruera E, Strasser F, Shen L, et al. The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: A pilot study. J Pain Symptom Manage. 2003;26:1049–1054
  166. Shaw EG, Rosdhal R, D'Agostino RB, et al. Phase II study of donepezil in irradiated brain tumor patients: Effect on cognitive function, mood, and quality of life. J Clin Oncol. 2006;24:1415–1420
  167. Bruera E, El Osta B, Valero V, et al. Donepezil for cancer fatigue: A double-blind, randomized, placebo-controlled trial. J Clin Oncol. 2007;25:3475–3481
  168. Auret KA, Schug SA, Bremner AP, Bulsara M. A randomized, double-blind, placebo-controlled trial assessing the impact of dexamphetamine on fatigue in patients with advanced cancer. J Pain Symptom Manage. 2009;37:613–621
  169. Lower EE, Fleishman S, Cooper A, et al. Efficacy of dexmethylphenidate for the treatment of fatigue after cancer chemotherapy: A randomized clinical trial. J Pain Symptom Manage. 2009;38:650–662
  170. Butler JM, Case LD, Atkins J, et al. A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2007;69:1496–1501
  171. Mar Fan HG, Clemons M, Xu W, et al. A randomised, placebo-controlled, double-blind trial of the effects of d-methylphenidate on fatigue and cognitive dysfunction in women undergoing adjuvant chemotherapy for breast cancer. Support Care Cancer. 2008;16:577–583
  172. Bruera E, Valero V, Driver L, et al. Patient-controlled methylphenidate for cancer fatigue: A double-blind, randomized, placebo-controlled trial. J Clin Oncol. 2006;24:2073–2078
  173. Hanna A, Sledge G, Mayer ML, et al. A phase II study of methylphenidate for the treatment of fatigue. Support Care Cancer. 2006;14:210–215
  174. Johnson RL, Block I, Gold MA, Markwell S, Zupancic M. Effect of methylphenidate on fatigue in women with recurrent gynecologic cancer. Psychooncology. Nov 16, 2009;Epub
  175. Bruera E, Driver L, Barnes EA, et al. Patient-controlled methylphenidate for the management of fatigue in patients with advanced cancer: A preliminary report. J Clin Oncol. 2003;21:4439–4443
  176. Sarhill N, Walsh D, Nelson KA, Homsi J, LeGrand S, Davis MP. Methylphenidate for fatigue in advanced cancer: A prospective open-label pilot study. Am J Hosp Palliat Care. 2001;18:187–192
  177. Schwartz A, Thompson J, Masood N. Interferon-induced fatigue in patients with melanoma: A pilot study of exercise and methylphenidate. Oncol Nurs Forum. 2002;29:E85–E90
  178. Sugawara Y, Akechi T, Shima Y, et al. Efficacy of methylphenidate for fatigue in advanced cancer patients: A preliminary study. Palliat Med. 2002;16:261–263
  179. Morrow GR, Hickok JT, Roscoe JA, et al. Differential effects of paroxetine on fatigue and depression: A randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program. J Clin Oncol. 2003;21:4635–4641
  180. Roscoe JA, Morrow GR, Hickok JT, et al. Effect of paroxetine hydrochloride (Paxil) on fatigue and depression in breast cancer patients receiving chemotherapy. Breast Cancer Res. 2005;89:243–249
  181. Weitzner MA, Moncello J, Jacobsen PB, Minton S. A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer. J Pain Symptom Manage. 2002;23:337–345
  182. Zick SM, Sen A, Feng Y, Green J, Olatunde S, Boon H. Trial of essiac to ascertain its effect in women with breast cancer (TEA-BC). J Alternative Complementary Med. 2006;12:971–980
  183. Barton DL, Soori GS, Bauer BA, et al. Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: A randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Support Care Cancer. 2010;18:179–187
  184. Schumacher K, Schneider B, Reich G, et al. Influence of postoperative complementary treatment with lectin-standardized mistletoe extract on breast cancer patients (A controlled epidemiological multicentric retrolective cohort study). Anticancer Res. 2003;23:5081–5087
  185. Beuth J, Schneider B, Schierholz JM. Impact of complementary treatment of breast cancer patients with standardized mistletoe extract during aftercare: A controlled multicenter comparative epidemiological cohort study. Anticancer Res. 2008;28:523–527
  186. Cruciani RA, Dvorkin E, Homel P, et al. L-carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency: A preliminary analysis. Ann N Y Acad Sci. 2004;1033:168–176
  187. Cruciani RA, Dvorkin E, Homel P, et al. Safety, tolerability and symptom outcomes associated with L-carnitine supplementation in patients with cancer, fatigue, and carnitine deficiency: A phase I/II study. J Pain Symptom Manage. 2006;32:551–559
  188. Gramignano G, Lusso MR, Madeddu C, et al. Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy. Nutrition. 2006;22:136–145
  189. Graziano F, Bisonni R, Catalano V, et al. Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anaemic cancer patients. Br J Cancer. 2002;86:1854–1857
  190. Cruciani RA, Dvorkin E, Homel P, et al. L-carnitine supplementation in patients with advanced cancer and carnitine deficiency: A double-blind, placebo-controlled study. J Pain Symptom Manage. 2009;37:622–631
  191. Yeom CH, Jung GC, Song KJ. Changes of terminal cancer patients' health-related quality of life after high dose vitamin C administration. J Korean Med Sci. 2007;22:7–11
  192. Blackhall L, Petroni G, Shu J, Baum L, Farace E. A pilot study evaluating the safety and efficacy of modafinal for cancer-related fatigue. J Palliat Med. 2009;12:433–439
  193. Cooper MR, Bird HM, Steinberg M. Efficacy and safety of modafinil in the treatment of cancer-related fatigue. Ann Pharmacother. 2009;43:721–725
  194. Spathis A, Dhillan R, Booden D, Forbes K, Vrotsou K, Fife K. Modafinil for the treatment of fatigue in lung cancer: A pilot study. Palliat Med. 2009;23:325–331
  195. Read JA, Beale PJ, Volker DH, Smith N, Childs A, Clarke SJ. Nutrition intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer (Effects on nutritional and inflammatory status: A phase II trial). Support Care Cancer. 2007;15:301–307
  196. Bruera E, Strasser F, Palmer JL, et al. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: A double-blind, placebo-controlled study. J Clin Oncol. 2003;21:129–134
  197. da Costa Miranda V, Trufelli DC, Santos J, et al. Effectiveness of guarana (Paullinia cupana) for postradiation fatigue and depression: Results of a pilot double-blind randomized study. J Altern Complement Med. 2009;15:431–433
  198. Kamath J, Yarbrough GG, Prange AJ, Winokur A. Thyrotropin-releasing hormone can relieve cancer-related fatigue: Hypothesis and preliminary observations. J Int Med Res. 2009;37:1152–1157
  199. Khan QJ, Reddy PS, Kimler BF, et al. Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer. Breast Cancer Res Treat. 2010;119:111–118
  200. Mantovani G, Maccio A, Madeddu C, et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev. 2006;15:1030–1034
  201. Cerchietti LC, Navigante AH, Peluffo GD, et al. Effects of celecoxib, medroxyprogesterone, and dietary intervention on systemic syndromes in patients with advanced lung adenocarcinoma: A pilot study. J Pain Symptom Manage. 2004;27:85–95
  202. Jensen MB, Hessov I. Randomization to nutritional intervention at home did not improve postoperative function, fatigue or well-being. Br J Surg. 1997;84:113–118
  203. Gadsby JG, Franks A, Jarvis P, Dewhurst F. Acupuncture-like transcutaneous electrical nerve stimulation within palliative care: A pilot study. Complementary Ther Med. 1997;5:13–18
  204. Mao JJ, Bruner DW, Stricker C, et al. Feasibility trial of electroacupuncture for aromatase inhibitor-related arthralgia in breast cancer survivors. Integr Cancer Ther. 2009;8:123–129
  205. Balk J, Day R, Rosenzweig M, Beriwal S. Pilot, randomized, modified, double-blind, placebo-controlled trial of acupuncture for cancer-related fatigue. J Soc Integr Oncol. 2009;7:4–11
  206. Vickers AJ, Straus DJ, Fearon B, Cassileth BR. Acupuncture for postchemotherapy fatigue: A phase II study. J Clin Oncol. 2004;22:1731–1735
  207. Mao JJ, Styles T, Cheville A, Wolf J, Fernandes S, Farrar JT. Acupuncture for nonpalliative radiation therapy-related fatigue: Feasibility study. J Soc Integr Oncol. 2009;7:52–58
  208. Davidson JR, Waisberg JL, Brundage MD, Maclean AW. Nonpharmacologic group treatment of insomnia: A preliminary study with cancer survivors. Psycho-Oncology. 2001;10:389–397
  209. Espie CA, Fleming L, Cassidy J, et al. Randomized controlled clinical effectiveness trial of cognitive behavior therapy compared with treatment as usual for persistent insomnia in patients with cancer. J Clin Oncol. 2008;26:4651–4658
  210. Savard J, Simard S, Ivers H, Morin CM. Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part I: Sleep and psychological effects. J Clin Oncol. 2005;23:6083–6096
  211. Gielissen MF, Verhagen S, Witjes F, Bleijenberg G. Effects of cognitive behavior therapy in severely fatigued disease-free cancer patients compared with patients waiting for cognitive behavior therapy: A randomized controlled trial. J Clin Oncol. 2006;24:4882–4887
  212. Dirksen SR, Epstein DR. Efficacy of an insomnia intervention on fatigue, mood and quality of life in breast cancer survivors. J Adv Nurs. 2008;61:664–675
  213. Quesnel C, Savard J, Simard S, Ivers H, Morin CM. Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer. J Consulting Clin Psychol. 2003;71:189–200
  214. Dalton JA, Keefe FJ, Carlson J, Youngblood R. Tailoring cognitive-behavioral treatment for cancer pain. Pain Manag Nurs. 2004;5:3–18
  215. Strong V, Waters R, Hibberd C, et al. Management of depression for people with cancer (SMaRT oncology 1): A randomised trial. Lancet. 2008;372:40–48
  216. Berger AM, VonEssen S, Khun BR, et al. Feasibility of a sleep intervention during adjuvant breast cancer chemotherapy. Oncology Nursing Forum. 2002;29:1431–1441
  217. Berger AM, VonEssen S, Kuhn BR, et al. Adherence, sleep, and fatigue outcomes after adjuvant breast cancer chemotherapy: Results of a feasibility intervention study. Oncology Nursing Forum. 2003;30:513–522
  218. Gaston-Johansson F, Fall-Dickson JM, Nanda J, et al. The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation. Cancer Nurs. 2000;23:277–285
  219. Berger AM, Kuhn BR, Farr LA, et al. Behavioral therapy intervention trial to improve sleep quality and cancer-related fatigue. Psychooncology. 2009;18:634–646
  220. Savard J, Simard S, Giguere I, et al. Randomized clinical trial on cognitive therapy for depression in women with metastatic breast cancer: Psychological and immunological effects. Palliat Support Care. 2006;4:219–237
  221. Levesque M, Savard J, Simard S, Gauthier JG, Ivers H. Efficacy of cognitive therapy for depression among women with metastatic cancer: A single-case experimental study. J Behav Ther Exp Psychiatry. 2004;35:287–305
  222. Montgomery GH, Kangas M, David D, et al. Fatigue during breast cancer radiotherapy: An initial randomized study of cognitive-behavioral therapy plus hypnosis. Health Psychol. 2009;28:317–322
  223. Schnur JB, Montgomery GH. Hypnosis and cognitive-behavioral therapy during breast cancer radiotherapy: A case report. Am J Clin Hypn. 2008;50:209–215
  224. Courneya KS, Friedenreich CM, Sela RA, Quinney HA, Rhodes RE, Handman M. The group psychotherapy and home-based physical exercise (group-hope) trial in cancer survivors: Physical fitness and quality of life outcomes. Psychooncology. 2003;12:357–374
  225. Goodwin PJ, Leszcz M, Ennis M, et al. The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med. 2001;345:1719–1726
  226. Aghabati N, Mohammadi E, Pour Esmaiel Z. The effect of therapeutic touch on pain and fatigue of cancer patients undergoing chemotherapy. Evid Based Complement Alternat Med. Feb 2, 2008;Epub
  227. Danhauer SC, Tooze JA, Holder P, Miller C, Jesse MT. Healing touch as a supportive intervention for adult acute leukemia patients: A pilot investigation of effects on distress and symptoms. J Soc Integr Oncol. 2008;6:89–97
  228. Montgomery GH, Bovbjerg DH, Schnur JB, et al. A randomized clinical trial of a brief hypnosis intervention to control side effects in breast surgery patients. J Natl Cancer Inst. 2007;99:1304–1312
  229. van Weert E, Hoekstra-Weebers J, Otter R, Postema K, Sanderman R, van der Schans C. Cancer-related fatigue: Predictors and effects of rehabilitation. Oncologist. 2006;11:184–196
  230. Riesenberg H, Lubbe AS. In-patient rehabilitation of lung cancer patients—a prospective study. Support Care Cancer, in press.
  231. Buss T, de Walden-Galuszko K, Modlinska A, Osowicka M, Lichodziejewska-Niemierko M, Janiszewska J. Kinesitherapy alleviates fatigue in terminal hospice cancer patients—an experimental, controlled study. Support Care Cancer, in press.
  232. Heim ME, v d Malsburg ML, Niklas A. Randomized controlled trial of a structured training program in breast cancer patients with tumor-related chronic fatigue. Onkologie. 2007;30:429–434
  233. Korstjens I, May AM, van Weert E, et al. Quality of life after self-management cancer rehabilitation: A randomized controlled trial comparing physical and cognitive-behavioral training versus physical training. Psychosom Med. 2008;70:422–429
  234. van Weert E, Hoekstra-Weebers JE, May AM, Korstjens I, Ros WJ, van der Schans CP. The development of an evidence-based physical self-management rehabilitation programme for cancer survivors. Patient Educ Couns. 2008;71:169–190
  235. Post-White J, Kinney ME, Savik K, Gau JB, Wilcox C, Lerner I. Therapeutic massage and healing touch improve symptoms in cancer. Integrative Cancer Therapies. 2003;2:332–344
  236. Currin J, Meister EA. A hospital-based intervention using massage to reduce distress among oncology patients. Cancer Nurs. 2008;31:214–221
  237. Cassileth BR, Vickers AJ. Massage therapy for symptom control: Outcome study at a major cancer center. J Pain Symptom Manage. 2004;28:244–249
  238. Ahles TA, Tope DM, Pinkson B, et al. Massage therapy for patients undergoing autologous bone marrow transplantation. J Pain Symptom Manage. 1999;18:157–163
  239. Pruthi S, Degnim AC, Bauer BA, DePompolo RW, Nayar V. Value of massage therapy for patients in a breast clinic. Clin J Oncol Nurs. 2009;13:422–425
  240. Kieviet-Stijnen A, Visser A, Garssen B, Hudig W. Mindfulness-based stress reduction training for oncology patients: Patients' appraisal and changes in well-being. Patient Educ Couns. 2008;72:436–442
  241. Carlson LE, Garland SN. Impact of Mindfulness-Based Stress Reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients. Int J Behav Med. 2005;12:278–285
  242. Speca M, Carlson LE, Goodey E, Angen M. A randomized, wait-list controlled clinical trial: The effect of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients. Psychosom Med. 2000;62:613–622
  243. Carlson LE, Speca M, Patel KD, Goodey E. Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress, and immune parameters in breast and prostate cancer outpatients. Psychosom Med. 2003;65:571–581
  244. Lengacher CA, Johnson-Mallard V, Post-White J, et al. Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer. Psychooncology. 2009;18:1261–1272
  245. Clark M, Isaacks-Downton G, Wells N, et al. Use of preferred music to reduce emotional distress and symptom activity during radiation therapy. J Music Ther. 2006;43:247–265
  246. Bozcuk H, Artac M, Kara A, et al. Does music exposure during chemotherapy improve quality of life in early breast cancer patients? (A pilot study). Med Sci Monitor. 2006;12:CR200–CR205
  247. Burns DS, Azzouz F, Sledge R, et al. Music imagery for adults with acute leukemia in protective environments: A feasibility study. Support Care Cancer. 2008;16:507–513
  248. Nakayama H, Kikuta F, Takeda H. A pilot study on effectiveness of music therapy in hospice in Japan. J Music Ther. 2009;46:160–172
  249. Roscoe JA, Matteson SE, Mustian KM, Padmanaban D, Morrow GR. Treatment of radiotherapy-induced fatigue through a nonpharmacological approach. Integr Cancer Ther. 2005;4:8–13
  250. Cohen M, Fried G. Comparing Relaxation training and cognitive-behavioral group therapy for women with breast cancer. Res Social Work Practice. 2007;17:313–323
  251. Decker TW, Cline-Elsen J, Gallagher M. Relaxation therapy as an adjunct in radiation oncology. J Clin Psychol. 1992;48:388–393
  252. Haase O, Schwenk W, Hermann C, Muller JM. Guided imagery and relaxation in conventional colorectal resections: A randomized, controlled, partially blinded trial. Dis Colon Rectum. 2005;48:1955–1963
  253. Luebbert K, Dahme B, Hasenbring M. The effectiveness of relaxation training in reducing treatment-related symptoms and improving emotional adjustment in acute non-surgical cancer treatment: A meta-analytical review. Psychooncology. 2001;10:490–502
  254. Brown P, Clark MM, Atherton P, et al. Will improvement in quality of life (QOL) impact fatigue in patients receiving radiation therapy for advanced cancer?. Am J Clin Oncol. 2006;29:52–58
  255. Ream E, Richardson A, Alexander-Dann C. Supportive intervention for fatigue in patients undergoing chemotherapy: A randomized controlled trial. J Pain Symptom Manage. 2006;31:148–161
  256. Dolbeault S, Cayrou S, Bredart A, et al. The effectiveness of a psycho-educational group after early-stage breast cancer treatment: Results of a randomized French study. Psychooncology. 2009;18:647–656
  257. Godino C, Jodar L, Duran A, Martinez I, Schiaffino A. Nursing education as an intervention to decrease fatigue perception in oncology patients. Eur J Oncol Nurs. 2006;10:150–155
  258. Vilela LD, Nicolau B, Mahmud S, et al. Comparison of psychosocial outcomes in head and neck cancer patients receiving a coping strategies intervention and control subjects receiving no intervention. J Otolaryngol. 2006;35:88–96
  259. Boesen EH, Ross L, Frederiksen K, et al. Psychoeducational intervention for patients with cutaneous malignant melanoma: A replication study. J Clin Oncol. 2005;23:1270–1277
  260. Lindemalm C, Strang P, Lekander M Support group for cancer patients. Does it improve their physical and psychological wellbeing? (A pilot study). Support Care Cancer. 2005;13:652–657
  261. Williams SA, Schreier AM. The role of education in managing fatigue, anxiety, and sleep disorders in women undergoing chemotherapy for breast cancer. Appl Nurs Res. 2005;18:138–147
  262. Yates P, Aranda S, Hargraves M, et al. Randomized controlled trial of an educational intervention for managing fatigue in women receiving adjuvant chemotherapy for early-stage breast cancer. J Clin Oncol. 2005;23:6027–6036
  263. Allison PJ, Edgar L, Nicolau B, Archer J, Black M, Hier M. Results of a feasibility study for a psycho-educational intervention in head and neck cancer. Psychooncology. 2004;13:482–485
  264. Given B, Given CW, McCorkle R, et al. Pain and fatigue management: Results of a nursing randomized clinical trial. Oncol Nurs Forum. 2002;29:949–956
  265. Fawzy FI. A short-term psychoeducational intervention for patients newly diagnosed with cancer. Support Care Cancer. 1995;3:235–238
  266. Fawzy FI, Cousins N, Fawzy NW, Kemeny ME, Elashoff R, Morton D. A structured psychiatric intervention for cancer patients (I. Changes over time in methods of coping and affective disturbance). Arch Gen Psychiatry. 1990;47:720–725
  267. Kim Y, Roscoe JA, Morrow GR. The effects of information and negative effect on severity of side effects from radiation therapy for prostate cancer. Support Care Cancer. 2002;10:416–421
  268. Yesilbalkan OU, Karadakovan A, Goker E. The effectiveness of nursing education as an intervention to decrease fatigue in Turkish patients receiving chemotherapy. Oncol Nurs Forum. 2009;36:E215–E222
  269. Oh B, Butow P, Mullan B, et al. Impact of Medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: A randomized controlled trial. Ann Oncol. 2010;21:608–614
  270. Tsang KL, Carlson LE, Olson K. Pilot crossover trial of Reiki versus rest for treating cancer-related fatigue. Integrative Cancer Ther. 2007;6:25–35
  271. Kim SD, Kim HS. Effects of a relaxation breathing exercise on anxiety, depression, and leukocyte in hemopoietic stem cell transplantation patients. Cancer Nurs. 2005;28:79–83
  272. Schneider SM, Ellis M, Coombs WT, Shonkwiler EL, Folsom LC. Virtual reality intervention for older women with breast cancer. Cyberpsychol Behav. 2003;6:301–307
  273. Schneider SM, Hood LE. Virtual reality: A distraction intervention for chemotherapy. Oncol Nurs Forum. 2007;34:39–46
  274. Schneider SM, Prince-Paul M, Allen MJ, Silverman P, Talaba D. Virtual reality as a distraction intervention for women receiving chemotherapy. Oncol Nurs Forum. 2004;31:81–88
  275. Oyama H, Kaneda M, Katsumata N, Akechi T, Ohsuga M. Using the bedside wellness system during chemotherapy decreases fatigue and emesis in cancer patients. J Med Syst. 2000;24:173–182
  276. Oyama H, Ohsuga M, Tatsuno Y, Katsumata H. Evaluation of the psycho-oncological effectiveness of the bedside wellness system. Cyberpsychol Behav. 1999;2:81–84
  277. Danhauer SC, Tooze JA, Farmer DF, et al. Restorative yoga for women with ovarian or breast cancer: Findings from a pilot study. J Soc Integr Oncol. 2008;6:47–58
  278. Carson JW, Carson KM, Porter LS, Keefe FJ, Shaw H, Miller JM. Yoga for women with metastatic breast cancer: Results from a pilot study. J Pain Symptom Manage. 2007;33:331–341
  279. Culos-Reed SN, Carlson LE, Daroux LM, Hately-Aldous S. A pilot study of yoga for breast cancer survivors: Physical and psychological benefits. Psychooncology. 2006;15:891–897
  280. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer. 2004;100:2253–2260
  281. Moadel AB, Shah C, Wylie-Rosett J, et al. Randomized controlled trial of yoga among a multiethnic sample of breast cancer patients: Effects on quality of life. J Clin Oncol. 2007;25:4387–4395
  282. Danhauer SC, Mihalko SL, Russell GB, et al. Restorative yoga for women with breast cancer: Findings from a randomized pilot study. Psychooncology. 2009;18:360–368
  283. Carson JW, Carson KM, Porter LS, Keefe FJ, Seewaldt VL. Yoga of Awareness program for menopausal symptoms in breast cancer survivors: Results from a randomized trial. Support Care Cancer. 2009;17:1301–1309
  284. Strauss-Blasche G, Gnad E, Ekmekcioglu C, Hladschik B, Marktl W. Combined inpatient rehabilitation and spa therapy for breast cancer patients: Effects on quality of life and CA 15-3. Cancer Nursing. 2005;28:390–398
  285. Kohara H, Miyauchi T, Suehiro Y, Ueoka H, Takeyama H, Morita T. Combined modality treatment of aromatherapy, footsoak, and reflexology relieves fatigue in patients with cancer. J Palliative Med. 2004;7:791–796
  286. Dy SM, Lorenz KA, Naeim A, Sanati H, Walling A, Asch SM. Evidence-based recommendations for cancer fatigue, anorexia, depression, and dyspnea. J Clin Oncol. 2008;26:3886–3895
  287. Escalante CP, Manzullo EF. Cancer-related fatigue: The approach and treatment. J Gen Intern Med. 2009;24(Suppl 2):S412–S416
  288. Mustian KM, Sprod LK, Palesh OG, et al. Exercise for the management of side effects and quality of life among cancer survivors. Curr Sports Med Rep. 2009;8:325–330
  289. Conn VS, Hafdahl AR, Porock DC, McDaniel R, Nielsen PJ. A meta-analysis of exercise interventions among people treated for cancer. Support Care Cancer. 2006;14:699–712
  290. Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G. Physical exercise in cancer patients during and after medical treatment: A systematic review of randomized and controlled clinical trials. J Clin Oncol. 2005;23:3830–3842
  291. McNeely ML, Campbell KL, Rowe BH, Klassen TP, Mackey JR, Courneya KS. Effects of exercise on breast cancer patients and survivors: A systematic review and meta-analysis. CMAJ. 2006;175:34–41
  292. Galvao DA, Newton RU. Review of exercise intervention studies in cancer patients. J Clin Oncol. 2005;23:899–909
  293. Kuchinski AM, Reading M, Lash AA. Treatment-related fatigue and exercise in patients with cancer: A systematic review. Medsurg Nurs. 2009;18:174–180
  294. Speck RM, Courneya KS, Masse LC, Duval S, Schmitz KH. An update of controlled physical activity trials in cancer survivors: A systematic review and meta-analysis. J Cancer Surviv, in press.
  295. Thorsen L, Courneya KS, Stevinson C, Fosså SD. A systematic review of physical activity in prostate cancer survivors: Outcomes, prevalence, and determinants. Support Care Cancer. 2008;16:987–997
  296. Labourey JL. Physical activity in the management of cancer-related fatigue induced by oncological treatments. Ann Readapt Med Phys. 2007;50:450–454445-459
  297. Seo Y, Oh H, Seo W. Causal relationships among factors associated with cancer-related fatigue. Eur J Oncol Nurs, in press.
  298. Klika RJ, Callahan KE, Drum SN. Individualized 12-week exercise training programs enhance aerobic capacity of cancer survivors. Phys Sportsmed. 2009;37:68–77
  299. Spence RR, Heesch KC, Brown WJ. Exercise and cancer rehabilitation: A systematic review. Cancer Treat Rev. 2010;36:185–194
  300. McAuley E, White SM, Rogers LQ, Motl RW, Courneya KS. Physical activity and fatigue in breast cancer and multiple sclerosis: Psychosocial mechanisms. Psychosom Med. 2010;72:88–96
  301. Speed-Andrews AE, Courneya KS. Effects of exercise on quality of life and prognosis in cancer survivors. Curr Sports Med Rep. 2009;8:176–181
  302. Humpel N, Iverson DC. Review and critique of the quality of exercise recommendations for cancer patients and survivors. Support Care Cancer. 2005;13:493–502
  303. Donnelly CM, Lowe-Strong A, Rankin JP, Campbell A, Allen JM, Gracey JH. Physiotherapy management of cancer-related fatigue: A survey of UK current practice. Support Care Cancer, in press.
  304. White SM, McAuley E, Estabrooks PA, Courneya KS. Translating physical activity interventions for breast cancer survivors into practice: An evaluation of randomized controlled trials. Ann Behav Med. 2009;37:10–19
  305. Jacobsen PB, Donovan KA, Vadaparampil ST, Small BJ. “Systematic review and meta-analysis of psychological and activity-based interventions for cancer-related fatigue”: Correction. Health Psychol. 2008;27:42
  306. Barsevick AM, Dudley W, Beck S, Sweeney C, Whitmer K, Nail L. A randomized clinical trial of energy conservation for patients with cancer-related fatigue. Cancer. 2004;100:1302–1310
  307. Barsevick AM, Whitmer K, Sweeney C, Nail LM. A pilot study examining energy conservation for cancer treatment-related fatigue. Cancer Nurs. 2002;25:333–341
  308. Korstjens I, Mesters I, van der Peet E, Gijsen B, van den Borne B. Quality of life of cancer survivors after physical and psychosocial rehabilitation. Eur J Cancer Prev. 2006;15:541–547
  309. Carpenter JS, Storniolo AM, Johns S, et al. Randomized, double-blind, placebo-controlled crossover trials of venlafaxine for hot flashes after breast cancer. Oncologist. 2007;12:124–135
  310. Lasheen W, Walsh D, Mahmoud F, Davis MP, Rivera N, Khoshknabi DS. Methylphenidate side effects in advanced cancer: A retrospective analysis. Am J Hosp Palliat Care. 2010;27:16–23
  311. Kohli S, Fisher SG, Tra Y, et al. The effect of modafinil on cognitive function in breast cancer survivors. Cancer. 2009;115:2605–2616
  312. Wilson J, Yao GL, Raftery J, et al. A systematic review and economic evaluation of epoetin alfa, epoetin beta and darbepoetin alfa in anaemia associated with cancer, especially that attributable to cancer treatment. Health Technol Assess. 2007;11:1–220
  313. Jones M, Schenkel B, Just J, Fallowfield L. Epoetin alfa improves quality of life in patients with cancer: Results of metaanalysis. Cancer. 2004;101:1720–1732
  314. Bottomley A, Thomas R, van Steen K, Flechtner H, Djulbegovic B. Human recombinant erythropoietin and quality of life: A wonder drug or something to wonder about?. Lancet Oncol. 2002;3:145–153
  315. Cella D, Dobrez D, Glaspy J. Control of cancer-related anemia with erythropoietic agents: A review of evidence for improved quality of life and clinical outcomes. Ann Oncol. 2003;14:511–519
  316. Littlewood TJ, Cella D, Nortier JW. Erythropoietin improves quality of life. Lancet Oncol. 2002;3:459–460
  317. Bohlius J, Schmidlin K, Brillant C, et al. Erythropoietin or darbepoetin for patients with cancer—meta-analysis based on individual patient data. Cochrane Database Syst Rev. 2009;(3):CD007303
  318. Glaspy J, Crawford J, Vansteenkiste J, et al. Erythropoiesis-stimulating agents in oncology: A study-level meta-analysis of survival and other safety outcomes. Br J Cancer. 2010;102:301–315
  319. Stasi R, Amadori S, Littlewood TJ, Terzoli E, Newland AC, Provan D. Management of cancer-related anemia with erythropoietic agents: Doubts, certainties, and concerns. Oncologist. 2005;10:539–554
  320. Steensma DP, Loprinzi CL. Erythropoietin use in cancer patients: A matter of life and death?. J Clin Oncol. 2005;23:5865–5868
  321. Littlewood T, Collins G. Epoetin alfa: Basic biology and clinical utility in cancer patients. Expert Rev Anticancer Ther. 2005;5:947–956
  322. Hershman DL, Buono DL, Malin J, McBride R, Tsai WY, Neugut AI. Patterns of use and risks associated with erythropoiesis-stimulating agents among Medicare patients with cancer. J Natl Cancer Inst. 2009;101:1633–1641
  323. Glaspy JA. The development of erythropoietic agents in oncology. Expert Opin Emerg Drugs. 2005;10:553–567
  324. Cancer- and chemotherapy-induced anemia (version 2.2010). National Comprehensive Cancer Network http://www.nccn.org/professionals/physician_gls/PDF/anemia.pdf2010;Accessed February 14, 2010
  325. Rizzo JD, Somerfield MR, Hagerty KL, et al. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology/American Society of Clinical Oncology clinical practice guideline update. Blood. 2008;111:25–41
  326. Jain S, Mills PJ. Biofield therapies: Helpful or full of hype? A best evidence synthesis. Int J Behav Med. 2010;17:1–16
  327. Kwekkeboom KL, Cherwin CH, Lee JW, Wanta B. Mind-body treatments for the pain-fatigue-sleep disturbance symptom cluster in persons with cancer. J Pain Symptom Manage. 2010;39:126–138
  328. Linden W, Satin JR. Avoidable pitfalls in behavioral medicine outcome research. Ann Behav Med. 2007;33:143–147

 This work was supported by the Clinical Center, National Institutes of Health, Bethesda, MD.

PII: S1934-1482(10)00292-3

doi: 10.1016/j.pmrj.2010.03.024

PM&R
Volume 2, Issue 5 , Pages 364-383 , May 2010

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