PM&R
Volume 2, Issue 3 , Pages 209-213 , March 2010

Making Sense of Intention-to-Treat

References 

  1. Weinstein JN, Tosteson TD, Lurie JD, et al. Surgical vs nonoperative treatment for lumbar disk herniation: The Spine Patient Outcomes Research Trial (SPORT): a randomized trial. JAMA. 2006;296:2441–2450
  2. Weinstein JN, Lurie JD, Tosteson TD, et al. Surgery vs non-operative treatment for lumbar disk herniation: the Spine Patient Outcomes Research Trial (SPORT) Observational Cohort. JAMA. 2006;296:2451–2459
  3. Coronary Drug Project Research Group. Influence of adherence to treatment and response of cholesterol on mortality in the coronary drug project. Engl J Med. 1980;303:1038–1041
  4. Montori VM, Guyatt GH. Intention-to-treat principle. CMAJ. 2001;165:1339–1341
  5. Prentice RL, Caan B, Chlebowski RT, et al. Low-fat dietary pattern and risk of invasive breast cancer: The Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA. 2006;295:629–642
  6. Hollis S, Campbell F. What is meant by intention to treat analysis? Survey of published randomized controlled trials. BMJ. 1999;319:670–674
  7. Gravel J, Opatrny L, Shapiro S. The intention-to-treat approach in randomized controlled trials: are authors saying what they do and doing what they say?. Clin Trials. 2007;4:350–356
  8. Fergusson D, Aaron SD, Guyatt G, Hébert P. Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ. 2002;325:652–654
  9. Iosief A, Alessandro M, Carlo R. Modified intention to treat: frequency, definition and implication for clinical trials. 15th Cochrane Colloquium, Sao Paulo, 23-27 October 2007 http://www.imbi.uni-freiburg.de/OJS/cca/index.php/cca/article/view/5036Accessed December 21, 2009

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(10)00006-7

doi: 10.1016/j.pmrj.2010.01.004

PM&R
Volume 2, Issue 3 , Pages 209-213 , March 2010