PM&R
Volume 1, Issue 11 , Pages 1019-1024 , November 2009

Comparing Eccentric Resistance Exercise in Prostate Cancer Survivors On and Off Hormone Therapy: A Pilot Study

The material in the manuscript was presented only as an abstract at the ACSM meeting in May 2009.

  • Pamela A. Hansen, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, University of Utah and Huntsman Cancer Hospital, 590 Wakara Way, Salt Lake City, UT 84108†
    • Corresponding Author InformationAddress correspondence to: P.A.H.
    • ,
  • Christopher B. Dechet, MD

      Affiliations

    • Department of Urology, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT‡
    • ,
  • Christina A. Porucznik, PhD, MSPH

      Affiliations

    • Department of Family and Preventive Medicine, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT§
    • ,
  • Paul C. LaStayo, PhD, PT

      Affiliations

    • Department of Physical Therapy, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT

Received 6 June 2009 ,Accepted 27 September 2009.

References 

  1. Cancer Facts and Figures 2007. Atlanta, GA: American Cancer Society; 2007;
  2. Hellerstedt B, Pienta K. The current state of hormonal therapy for prostate cancer. CA Cancer J Clin. 2002;52:154–179
  3. Jemal A, Tiwari R, Murray T, et al. Cancer statistics. CA Cancer J Clin. 2004;54:8–29
  4. Williams M, Hernandez J, Thompson I. Luteinizing hormone-releasing hormone agonist effects on skeletal muscle: how hormonal therapy in prostate cancer affects muscular strength. J Urol. 2005;173:1067–1071
  5. Basaria S, Lieb J, Tang A, et al. Long-term effects of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol. 2002;56:779–786
  6. Bylow K, Dale W, Mustian K, et al. Falls and physical performance deficits in older patients with prostate cancer undergoing androgen deprivation therapy. Urology. 2008;72:422–427
  7. Cassileth B, Soloway M, Vogelzang N, et al. Quality of life and psychosocial status in stage D prostate cancer. Qual Life Res. 1992;1:323–330
  8. Cleary R, Morrissey G, Oster G. Health-related quality of life in patients with advanced prostate cancer: a multinational perspective. Qual Life Res. 1995;4:207–220
  9. Galvao D, Spry N, Taaffe D, et al. Changes in muscle, fat and bone mass after 36 weeks of maximal androgen blockade for prostate cancer. BJU Int. 2008;102:44–47
  10. Galvao D, Taaffee D, Spry N, et al. Reduced muscle strength and functional performance in men with prostate cancer undergoing androgen suppression: A comprehensive cross-sectional investigation. Prostate Cancer Prostatic Dis. 2008 Oct 14;[Epub]
  11. Pickett M, Bruner D, Joseph A, et al. Prostate cancer elder alert: Living with treatment choices and outcomes. J Gerontol Nurs. 2000;26:22–34
  12. Smith M, Finelstein J, McGovern F, et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab. 2002;87:599–603
  13. Bylow K, Mohile S, Stadler W, Dale W. Does androgen deprivation therapy accelerate the development of frailty in older men with prostate cancer? (A conceptual review). Cancer. 2007;110:2604–2613
  14. Galvao D, Nosaka K, Taaffe D, et al. Resistance training and reduction of treatment side effects in prostate cancer patients. Med Sci Sports Exerc. 2006;38:2045–2052
  15. Monga U, Garber S, Thornby J, et al. Exercise prevents fatigue and improves quality of life in prostate cancer patients undergoing radiotherapy. Arch Phys Med Rehabil. 2007;88:1416–1422
  16. Segal R, Reid R, Courneya K, et al. Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol. 2008 Dec 8;[Epub]
  17. Segal R, Reid R, Courneya K, et al. Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol. 2003;21:1653–1659
  18. Hortobagyi T. The positives of negatives: clinical implications of eccentric resistance exercise in old adults. J Gerontol A Biol Sci Med Sci. 2003;58:M417–M418
  19. LaStayo PC, Ewy GA, Pierotti DD, Johns RK, Lindstedt S. The positive effects of negative work: Increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003;58:M419–M424
  20. Lastayo PC, Reich TE, Urquhart M, Hoppeler H, Lindstedt SL. Chronic eccentric exercise: Improvements in muscle strength can occur with little demand for oxygen. Am J Physiol. 1999;276:R611–R615
  21. LaStayo PC, Pierotti DJ, Pifer J, Hoppeler H, Lindstedt SL. Eccentric ergometry: increases in locomotor muscle size and strength at low training intensities. Am J Physiol Regul Integr Comp Physiol. 2000;278:R1282–R1288
  22. Lindstedt S, LaStayo P, Reich T. When active muscles lengthen: Properties and consequences of eccentric contractions. News Physiol Sci. 2001;16:256–261
  23. Dibble LE, Hale T, Marcus RL, Gerber JP, Lastayo PC. The safety and feasibility of high-force eccentric resistance exercise in persons with Parkinson's disease. Arch Phys Med Rehabil. 2006;87:1280–1282
  24. Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006;21:1444–1452
  25. Tracy BL, Ivey FM, Metter JE, Fleg JL, Siegel EL, Hurley BF. A more efficient magnetic resonance imaging-based strategy for measuring quadriceps muscle volume. Med Sci Sports Exerc. 2003;35:425–433
  26. Bischoff HA, Stähelin HB, Monsch AU, et al. Identifying a cut-off point for normal mobility: a comparison of the timed ‘up and go’ test in community-dwelling and institutionalised elderly women. Age Ageing. 2003;32:315–320
  27. Enright P, McBurnie M, Bittner V, et al. The 6-min walk test: A quick measure of functional status in elderly adults. Chest. 2003;123:325–327
  28. Steffen T, Hacker T, Mollinger L. Age and gender-related test performance in community-dwelling elderly people: Six-minute walk test, Berg balance scale, timed up and go test, and gait speeds. Phys Ther. 2002;82:128–137
  29. Cella D. Manual of the Functional Assessment of Chronic Illness Therapy (FACIT) Scales. Chicago, IL: Center on Outcomes Research and Education, Northwestern University; 1997;
  30. Esper P, Mo F, Chodak G, Sinner M, Cella D, Pienta K. Measuring quality of life in men with prostate cancer using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) instrument. Urology. 1997;50;:920–928
  31. Cella D, Nichol M, Eton D, Nelson J, Mulani P. Estimating clinically meaningful changes for the Functional Assessment of Cancer Therapy-Prostate: Results from a clinical trial of patients with metastatic hormone-refractory prostate cancer. Value Health. 2008 July 18;[Epub]
  32. Yellen S. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J Pain Symptom Manage. 1997;13:63–74
  33. Cella D, Eton D, Lai J, Peterman A, Merkel D. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002;6(246):547–561
  34. Kidde J, Marcus R, Dibble L, Smith S, LaStayo P. Regional muscle and whole body composition factors related to an older individual's level of mobility: A review. Physiother Can [in press].
  35. Fritz S, Lusardi M. White paper: “Walking speed: The sixth vital sign”. J Geriatr Phys Ther. 2009;32:321–325

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(09)01400-2

doi: 10.1016/j.pmrj.2009.09.016

PM&R
Volume 1, Issue 11 , Pages 1019-1024 , November 2009

Article Tools

* Image Usage & Resolution