PM&R
Volume 1, Issue 11 , Pages 1019-1024, November 2009

Comparing Eccentric Resistance Exercise in Prostate Cancer Survivors On and Off Hormone Therapy: A Pilot Study

The material in the manuscript was presented only as an abstract at the ACSM meeting in May 2009.

  • Pamela A. Hansen, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, University of Utah and Huntsman Cancer Hospital, 590 Wakara Way, Salt Lake City, UT 84108†
    • Corresponding Author InformationAddress correspondence to: P.A.H.
    • ,
  • Christopher B. Dechet, MD

      Affiliations

    • Department of Urology, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT‡
    • ,
  • Christina A. Porucznik, PhD, MSPH

      Affiliations

    • Department of Family and Preventive Medicine, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT§
    • ,
  • Paul C. LaStayo, PhD, PT

      Affiliations

    • Department of Physical Therapy, University of Utah and Huntsman Cancer Hospital, Salt Lake City, UT

Received 6 June 2009; accepted 27 September 2009.

Objectives

To determine the feasibility of an eccentric resistance exercise training protocol in men with prostate cancer and to assess whether men with prostate cancer who are receiving androgen deprivation therapy (ADT) have a blunted effect from the training as compared with prostate cancer survivors not receiving ADT.

Design

Prospective pilot study.

Setting

Academic medical center.

Participants

Sixteen men with prostate cancer (Gleason scores 3+3 to 4+4) were initially enrolled. Ten men (mean age 66, range 48-86) completed the study, 5 were currently receiving ADT. Analysis was performed on these 10 men.

Interventions

Subjects were evaluated at baseline. All men underwent a 12-week resistance exercise training protocol using a recumbent, high-force eccentric, leg cycle ergometer 3 times per week at a “somewhat hard” perceived exertion for 12 to 15 minutes. Preexercise and postexercise training changes were examined within and between groups.

Main Outcome Measures

Quadriceps muscle volume (magnetic resonance imaging), isometric knee extension strength, functional mobility (Timed Up and Go Test [TUG] and 6-minute walk [6MW]), health-related quality of life (FACT-P), and fatigue (FACIT-fatigue scale).

Results

The ADT group demonstrated significant within-group improvements in the 6MW (P = .01) and isometric knee extension strength (P = .03). This group also demonstrated a clinically relevant change in the FACT-P; however, this did not meet statistical significance. The non-ADT group demonstrated significant within-group improvements in the physical subscale of the FACT-P (P = .03) and an increase in muscle volume (P = .04). Their improvements in the TUG approached significance (P = .08). No between-group differences existed.

Conclusions

Eccentric resistance exercise was well tolerated, and both groups derived some benefits in strength and functional mobility. Men receiving ADT did not appear to have a blunted response to the exercise as compared with prostate cancer survivors not receiving ADT.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 
  • † Disclosure: 8, Intramural Grant Program at University of Utah
  • ‡ Disclosure: nothing to disclose
  • § Disclosure: nothing to disclose
  •  Disclosure: 8, Intramural Grant Program at the University of Utah; 9A, ad hoc nonpaid consultant for Eccentron

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(09)01400-2

doi:10.1016/j.pmrj.2009.09.016

PM&R
Volume 1, Issue 11 , Pages 1019-1024, November 2009

Article Tools

* Image Usage & Resolution