PM&R
Volume 1, Issue 5 , Pages 471-489 , May 2009

Hyperbaric Oxygen Therapy for Wound Healing and Limb Salvage: A Systematic Review

Received 30 August 2008 ,Accepted 8 March 2009.

References 

  1. Kosiak M. Etiology and pathology of ischemic ulcers. Arch Phys Med Rehab. 1959;40:62–69
  2. Goldman RJ, Popescu A, Thomas C, et al. Prevention and management of chronic wounds. In:  Braddom R editors. Physical Medicine & Rehabilitation. Philadelphia, PA: Saunders Elsevier; 2007;p. 685–708
  3. Physical Medicine and Rehabilitation, The Brody School of Medicine at East Carolina University. www.ecu.edu/rehab/2008;Accessed Nov 28, 2008
  4. American Board of Preventive Medicine. Undersea & hyperbaric medicine. www.abprevmed.org/uhm.cfm2008;Accessed Nov 28, 2008
  5. Feldmeier J. Hyperbaric oxygen 2003: indications and results: the Hyperbaric Oxygen Committee Report. Flagstaff, AZ: Undersea and Hyperbaric Medicine Society; 2003;
  6. Elliott D, Kindwall EP. Decompression sickness. In:  Kindwall EP,  Wheelan H editor. Hyperbaric medicine practice. 2nd ed, revised. Flagstaff, AZ: Best Publishing Company; 2004;p. 433–488
  7. Kindwall EP. A history of hyperbaric medicine. In:  Kindwall EP,  Wheelan H editor. Hyperbaric medicine practice. 2nd ed, revised. Flagstaff, AZ: Best Publishing Company; 2004;p. 1–20
  8. Davis JC, Hunt TK. Hyperbaric oxygen therapy. Bethesda, MD: Undersea and Hyperbaric Medicine Society; 1977;
  9. Undersea and Hyperbaric Medicine Society. www.uhms.org2008;Accessed Nov 29, 2008
  10. Kindwall EP. The monoplace chamber. In:  Kindwall EP,  Wheelan H editor. Hyperbaric medicine practice. 2nd ed, revised. Flagstaff, AZ: Best Publishing Company; 2004;p. 127–142
  11. Hart GB. The monoplace chamber. In:  Kindwall EP,  Wheelan H editor. Hyperbaric medicine practice. 2nd ed, revised. Flagstaff, AZ: Best Publishing Company; 2004;p. 99–124
  12. Bennett MH, Feldmeier J, Hampson N, et al. Hyperbaric oxygen therapy for late radiation tissue injury. Cochrane Database System Rev. 2005;3:
  13. McDonagh M, Helfand M, Carson S, et al. Hyperbaric oxygen therapy for traumatic brain injury: a systematic review of the evidence. [see comment] Arch Phys Med Rehab. 2004;85:1198–1204
  14. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. Br Med J. 2004;328:19
  15. Kranke P, Bennett M, Roeckl-Wiedmann I, et al. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database System Rev. 2004;2:
  16. Faglia E, Favales F, Aldeghi A, et al. Adjunctive systemic hyperbaric oxygen therapy in treatment of severe prevalently ischemic diabetic foot ulcer (A randomized study). [see comment] Diabetes Care. 1996;19:1338–1343
  17. Faglia E, Favales F, Aldeghi A, et al. Change in major amputation rate in a center dedicated to diabetic foot care during the 1980s: prognostic determinants for major amputation. J Diabetes Complications. 1998;12:96–102
  18. Abidia A, Laden G, Kuhan G, et al. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. [see comment] Eur J Vasc Endovasc Surg. 2003;25:513–518
  19. Kessler L, Bilbault P, Ortega F, et al. Hyperbaric oxygenation accelerates the healing rate of nonischemic chronic diabetic foot ulcers: a prospective randomized study. Diabetes Care. 2003;26:2378–2382
  20. Fife CE, Buyukcakir C, Otto GH, et al. The predictive value of transcutaneous oxygen tension measurement in diabetic lower extremity ulcers treated with hyperbaric oxygen therapy: a retrospective analysis of 1,144 patients. Wound Repair Regen. 2002;10(4):198–207
  21. Fife CE, Buyukcakir C, Otto G, et al. Factors influencing the outcome of lower-extremity diabetic ulcers treated with hyperbaric oxygen therapy. Wound Repair Regen. 2007;15(3):322–331
  22. Otto GH, Buyukcakir C, Fife CE. Effects of smoking on cost and duration of hyperbaric oxygen therapy for diabetic patients with non-healing wounds. Undersea Hyperbaric Med. 2000;27(2):83–89
  23. Doctor N, Pandya S, Supe A. Hyperbaric oxygen therapy in diabetic foot. J Postgrad Med. 1992;38(3):112–114
  24. Kalani M, Jorneskog G, Naderi N, et al. Hyperbaric oxygen (HBO) therapy in treatment of diabetic foot ulcers (Long-term follow-up). J Diabetes Complications. 2002;16(2):153–158
  25. Zamboni WA, Wong HP, Stephenson LL, et al. Evaluation of hyperbaric oxygen for diabetic wounds: a prospective study. Undersea Hyperbaric Med. 1997;24(3):175–179
  26. Baroni G, Porro T, Faglia E, et al. Hyperbaric oxygen in diabetic gangrene treatment. Diabetes Care. 1987;10(1):81–86
  27. Goldman R, Brewley B, Golden M. Electrotherapy re-oxygenates inframalleolar ischemic wounds on diabetic patients - a case series. Adv Skin Wound Care. 2002;15(May/June):112–120
  28. Margolis D. Foot ulcers and amputations in CRIC (FACRIC). In: 2005;p. 116–151Philadelphia
  29. Grolman RE, Wilkerson DK, Taylor J, et al. Transcutaneous oxygen measurements predict a beneficial response to hyperbaric oxygen therapy in patients with nonhealing wounds and critical limb ischemia. Am Surg. 2001;67(11):1072–1079
  30. Hammarlund C, Sundberg T. Hyperbaric oxygen reduced size of chronic leg ulcers: a randomized double-blind study. Plast Reconstruct Surg. 1994;93(4):829–833
  31. Weenig RH, Sewell LD, Davis MD, et al. Calciphylaxis: natural history, risk factor analysis, and outcome. J Am Acad Dermatol. 2007;56(4):569–579
  32. Weenig RH. Pathogenesis of calciphylaxis: Hans Selye to nuclear factor kappa-B. J Am Acad Dermatol. 2008;58(3):458–471
  33. Hruska K. Renal osteodystrophy. In:  Goldman L,  Ausiello D editor. Cecil textbook of medicine. Philadelphia, PA: Saunders Elsevier; 2008;p. 931–936
  34. Basile C, Montanaro A, Masi M, et al. Hyperbaric oxygen therapy for calcific uremic arteriolopathy: a case series. Jf Nephrol. 2002;15(6):676–680
  35. Mureebe L, Moy M, Balfour E, et al. Calciphylaxis: a poor prognostic indicator for limb salvage. J Vasc Surg. 2001;33(6):1275–1279
  36. Efrati S, Bergan J, Fishlev G, et al. Hyperbaric oxygen therapy for nonhealing vasculitic ulcers. Clin Exp Dermatol. 2007;32(1):12–17
  37. Zgonis T, Garbalosa JC, Burns P, et al. A retrospective study of patients with diabetes mellitus after partial foot amputation and hyperbaric oxygen treatment. [see comment] J Foot Ankle Surg. 2005;44(4):276–280
  38. Ciaravino ME, Friedell ML, Kammerlocher TC. Is hyperbaric oxygen a useful adjunct in the management of problem lower extremity wounds?. Ann Vasc Surg. 1996;10(6):558–562
  39. Sheffield P, Sheffield J. Complication rates for hyperbaric oxygen therapy patients and their attendants: a 22 year analysis. In:  Cramer F,  Sheffield P editor. Proceedings of the Fourteenth International Congress on Hyperbaric Medicine. San Francisco: Best Publishing Company; 2003;p. 312–318
  40. Zhao DW. Therapeutic effect of hyperbaric oxygen on recovery of surgically repaired peripheral nerve injury. Chung Hua Wai Ko Tsa Chih [Chinese Journal of Surgery]. 1991;29(2):118–120
  41. Reedy MB, Capen CV, Baker DP, et al. Hyperbaric oxygen therapy following radical vulvectomy: an adjunctive therapy to improve wound healing. Gynecol Oncol. 1994;53(1):13–16
  42. Friedman HI, Fitzmaurice M, Lefaivre JF, et al. An evidence-based appraisal of the use of hyperbaric oxygen on flaps and grafts. [Erratum: Plast Reconstr Surg. 2006 Aug;118(2):62e Note: Friedman, H I F [corrected to Friedman, HI]] Plast Reconstr Surg. 2006;117(7 Suppl):
  43. Saber AA, Yahya KZ, Rao A, et al. A new approach in the management of chronic nonhealing leg ulcers. J Invest Surg. 2005;18(6):321–323
  44. Mathieu D, Neviere R, Pellerin P, et al. Pedicle musculocutaneous flap transplantation: prediction of final outcome by transcutaneous oxygen measurements in hyperbaric oxygen. Plast Reconstr Surg. 1993;91(2):329–334
  45. Gonnering RS, Kindwall EP, Goldmann RW. Adjunct hyperbaric oxygen therapy in periorbital reconstruction. Arch Ophthalmol. 1986;104(3):439–443
  46. Friedman HI, Stonerock C, Brill A. Composite earlobe grafts to reconstruct the lateral nasal ala and sill. Ann Plast Surg. 2003;50(3):275–281
  47. Davis JC, Heckman JD, DeLee JC, et al. Chronic non-hematogenous osteomyelitis treated with adjuvant hyperbaric oxygen. J Bone Jt Surg Am. 1986;68(8):1210–1217
  48. Morrey BF, Dunn JM, Heimbach RD, et al. Hyperbaric oxygen and chronic osteomyelitis. Clin Orthop Related Res. 1979;144:121–127
  49. Chen CE, Ko JY, Fu TH, et al. Results of chronic osteomyelitis of the femur treated with hyperbaric oxygen: a preliminary report. Chang Gung Med J. 2004;27(2):91–97
  50. Chen CY, Lee SS, Chan YS, et al. Chronic refractory tibia osteomyelitis treated with adjuvant hyperbaric oxygen: a preliminary report. Changgeng Yi Xue Za Zhi. 1998;21(2):165–171
  51. Esterhai JL, Pisarello J, Brighton CT, et al. Adjunctive hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis. J Trauma Inj Infect Crit Care. 1987;27(7):763–768
  52. Mader JT, Hicks CA, Calhoun J. Bacterial osteomyelitis (Adjunctive hyperbaric oxygen therapy). Ortho Rev. 1989;18(5):581–585
  53. Oriani G, Meazza D, Favales F, et al. Hyperbaric oxygen therapy in diabetic gangrene. J Hyperbaric Med. 1990;5(3):171–175
  54. Berendt AR. Counterpoint: hyperbaric oxygen for diabetic foot wounds is not effective. [comment] Clin Infect Dis. 2006;43(2):193–198
  55. Londahl M, Katzman P, Nilsson A, et al. A prospective study: hyperbaric oxygen therapy in diabetics with chronic foot ulcers. J Wound Care. 2006;15(10):457–459
  56. Maynor ML, Moon RE, Camporesi EM, et al. Chronic osteomyelitis of the tibia: treatment with hyperbaric oxygen and autogenous microsurgical muscle transplantation. J South Ortho Assoc. 1998;7(1):43–57
  57. Goldman R. Update on growth factors and wound healing: past, present and future. Adv Skin Wound Care. 2004;17(1):24–35
  58. Cianci P. Advances in the treatment of the diabetic foot: Is there a role for adjunctive hyperbaric oxygen therapy?. Wound Repair Regen. 2004;12(1):2–10
  59. Buras JA, Stahl GL, Svoboda KK, et al. Hyperbaric oxygen downregulates ICAM-1 expression induced by hypoxia and hypoglycemia: the role of NOS. Am J Physiol Cell Physiol. 2000;278(2):C292–C302
  60. Lewis D, Goldztein H, Deschler D. Use of hyperbaric oxygen to enhance auricular composite graft survival in the rabbit model. Arch Facial Plast Surg. 2006;8(5):310–313
  61. Sheikh AY, Gibson JJ, Rollins MD, et al. Effect of hyperoxia on vascular endothelial growth factor levels in a wound model. Arch Surg. 2000;135(11):1293–1297
  62. Hopf HW, Gibson JJ, Angeles AP, et al. Hyperoxia and angiogenesis. Wound Repair Regen. 2005;13(6):558–564
  63. Goldstein LJ, Gallagher KA, Bauer SM, et al. Endothelial progenitor cell release into circulation is triggered by hyperoxia-induced increases in bone marrow nitric oxide. Stem Cells. 2006;24(10):2309–2318
  64. Clark J, Whelan HT. Oxygen toxicity. In:  Kindwall EP,  Whelan HT editor. Hyperbaric medicine practice. 2nd ed.. Flagstaff, AZ: Best Publishing Company; 2004;p. 69–82
  65. Kindwall EP. Contraindications and side effects to hyperbaric oxygen treatment. In:  Kindwall EP,  Whelan HT editor. Hyperbaric medicine practice. 2nd ed.. Flagstaff, AZ: Best Publishing Company; 2004;p. 83–97
  66. Weaver LK, Churchill S. Pulmonary edema associated with hyperbaric oxygen therapy. Chest. 2001;120(4):1407–1409
  67. Plafki C, Peters P, Almeling M, et al. Complications and side effects of hyperbaric oxygen therapy. Aviat Space Environ Med. 2000;71(2):119–124
  68. Cierny G, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003;(414):7–24
  69. MedCalc Statistical Software: Meta-analysis: odds ratio. http://www.medcalc.be/manual/meta-oddsratio.php2009;Accessed Jan 1, 2009
  70. McNutt LA, Wu C, Xue X, et al. Estimating the relative risk in cohort studies and clinical trials of common outcomes. Am J Epidemiol. 2003;157(10):940–943
  71. Falanga V. Venous ulceration. Dermatol Surg Oncol. 1993;19:764–771
  72. Sheffield P. Measuring tissue oxygen tension: a review. Undersea Hyperbaric Med. 1998;25:179–187
  73. Padberg F, Back T, Thompson P, et al. Transcutaneous oxygen (TcPO2) estimates probability of healing in the ischemic extremity. J Surg Res. 1996;60:365–369
  74. Goldman R, Brewley B, Zhou L, et al. Electrotherapy reverses inframalleolar ischemia: a retrospective, observational study. Adv Skin Wound Care. 2003;16(3):79–89
  75. Caputo G, Cavanagh P, Ulbrecht J, et al. Assessment and management of foot disease in patients with diabetes. N Engl J Med. 1994;331(13):854–860
  76. Kominsky S. Outpatient management of pedal complications. In:  Kominsky S editors. Medical and Surgical management of the diabetic foot. St Louis, MO: Mosby Year Book; 1994;p. 223–247
  77. Wagner F. The Dysvascular foot: a system for diagnosis and treatment. Foot Ankle. 1981;2(2):64–122

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(09)00256-1

doi: 10.1016/j.pmrj.2009.03.012

PM&R
Volume 1, Issue 5 , Pages 471-489 , May 2009