PM&R
Volume 1, Issue 5 , Pages 466-470 , May 2009

Emerging Technologies for Degenerative Disk Disease: Potential Synergy Between Biochemical Signaling and Spinal Biomechanics

  • Steven Leckie, MD

      Affiliations

    • Department of Orthopaedic Surgery, Ferguson Laboratory for Orthopaedic Research, University of Pittsburgh, Pittsburgh, PA†
    • ,
  • Gwendolyn Sowa, MD, PhD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 5th Ave Suite 201, Pittsburgh, PA 15213‡
    • Corresponding Author InformationAddress correspondence to: G.S.

Received 21 October 2008 ,Accepted 26 February 2009.

References 

  1. The Bone and Joint Decade (The Burden of Musculoskeletal Diseases in the United States). http://boneandjointburden.org/Accessed August 8, 2008
  2. Johnson WE, Roberts S. Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. J Anat. 2003;203:605–612
  3. Eyre DR, Muir H. Types I and II collagens in intervertebral disc (Interchanging radial distribution in annulus fibrosus). Biochem J. 1976;157(1):267–270
  4. Marchand F, Ahmed AM. Investigation of the laminate structure of lumbar disc annulus fibrosus. Spine. 1990;15(5):402–410
  5. Roberts S, Eisenstein SM, Menage J, Evans EH, Ashton IK. Mechanoreceptors in Intervertebral Discs. Spine. 1995;20(24):2645–2651
  6. Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Andreas G. Classification of age-related changes in lumbar intervertebral discs. Spine. 2002;27:2631–2644
  7. Kang JD, Georgescu H, McIntyre-Larkin L, Stefanovic-Racic M, Donaldson WF, Evans CH. Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E-2. Spine. 1996;21:271–277
  8. Saal JS, Franson RC, Dobrow R, Saal JA, White AH, Goldthwaite N. High levels of inflammatory phospholipase A2 activity in lumbar disc herniations. Spine. 1990;15:674–678
  9. Franson RC, Saal JS, Saal JA. Human disc phospholipase A2 is inflammatory. Spine. 1992;17:S129–S232
  10. Kang JD, Stefanovic-Racic M, McIntyre-Larkin L, Georgescu H, Evans CH. Toward a biochemical understanding of human intervertebral disc degeneration and herniation: Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine. 1997;22:1065–1073
  11. LeMaitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther. 2005;7:732–745
  12. Weiler C, Nerlich AG, Zipperer J, Bachmeier BE, Boos N. Expression of major matrix metalloproteinases is associated with intervertebral disc degradation and resorption. Eur Spine J. 2002;11:308–320
  13. Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol. 2004;204:47–54
  14. Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC, Eisenstein SM. Matrix metalloproteinases and aggrecanase: Their role in disorders of the human intervertebral disc. Spine. 2000;25:3005–3013
  15. Oegema TR, Johnson SL, Aguiar DJ, Ogilvie JW. Fibronectin and its fragments increase with degeneration in the human intervertebral disc. Spine. 2000;25:2742–2747
  16. Johnson WE, Roberts S. Human intervertebral disc cell morphology and cytoskeletal composition: A preliminary study of regional variations in health and disease. J Anat. 2003;203:605–612
  17. Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E. Compression-induced degeneration of the intervertebral disc: An in vivo mouse model and finite-element study. Spine. 1998;23:2493–2506
  18. Marras WS, Ferguson SA, Burr D, Davis KG, Gupta P. Functional impairment as a predictor of spine loading. Spine. 2005;30:729–737
  19. Luoma K, Riihimaki H, Raininko R, Luukkonen R, Lamminen A, Viikari-Juntura E. Lumbar disc degeneration in relation to occupation. Scand J Work Environ Health. 1998;24:358–366
  20. Baer AE, Laursen TA, Guilak F, Setton LA. The micromechanical environment of intervertebral disc cells determined by a finite deformation, anisotropic, and biphasic finite element model. J Biomechan Engin. 2003;125:1–11
  21. Walsh AJL, Lotz JC. Biological response of the intervertebral disc to dynamic loading. J Biomechan. 2004;37:329–337
  22. Wang DL, Jiang SD, Dai LY. Biologic response of the intervertebral disc to static and dynamic compression in vitro. Spine. 2007;32:2521–2528
  23. Handa T, Ishihara H, Ohshima H, Osada R, Tsuji H, Obata K. Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc. Spine. 1997;22:1085–1091
  24. Lotz J, Chin J. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading. Spine. 2000;25:1477–1483
  25. Sowa GA, Agarwal S. Cyclic tensile stress exerts a protective effect on intervertebral disc cells. Am J Phys Med Rehabil. 2008;87:537–544
  26. Iatridis JC, Mente PL, Stokes IA, Aronson DD, Alini M. Compression-induced changes in intervertebral disc properties in a rat tail model. Spine. 1999;24:996–1002
  27. Deyo RA, Diehl AK, Rosenthal M. How many days of bed rest for acute low back pain? (A randomized clinical trial). N Engl J Med. 1986;315:1064–1070
  28. Rainville J, Hartigan C, Martinez E, Limke J, Jouve C, Finno M. Exercise as a treatment for chronic low back pain. Spine. 2004;4:106–115
  29. Vad VB, Bhat AL, Tarabichi Y. The role of the back RX exercise program in diskogenic low back pain: A prospective randomized trial. Arch PhysMed Rehabil. 2007;88:577–582
  30. Wai EK, Rodriguez S, Dagenais S, Hall H. Evidence-informed management of chronic low back pain with physical activity, smoking cessation, and weight loss. Spine J. 2008;8:195–202
  31. Boyd LM, Richardson WJ, Chen J, Kraus VB, Tewari A, Setton LA. Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR. Ann Biomed Engin. 2005;33:1071–1077
  32. Kang JD, Stefanovic-Racic M, McIntyre-Larkin L, Georgescu H, Evans CH. Toward a biochemical understanding of human intervertebral disc degeneration and herniation: contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine. 1997;22:1065–1073
  33. Kobayashi S, Baba H, Uchida K, et al. Effect of mechanical compression on the lumbar nerve root: localization and changes of intraradicular inflammatory cytokines, nitric oxide, and cyclooxygenase. Spine. 2005;30:1699–1705
  34. An HS, Takegami K, Kamada H, et al. Intradiscal administration of osteogenic protein-1 increases intervertebral disc height and proteoglycan content in the nucleus pulposus in normal adolescent rabbits. Spine. 2004;30:25–32
  35. Louis-Ugbo J, Kim HS, Boden SD. Retention of 125I-labeled recombinant human bone morphogenetic protein-2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model. J Orthopaed Res. 2002;20:1050–1059
  36. Wallach CJ, Sobajima S, Watanabe Y, et al. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs. Spine. 2003;28:2331–2337
  37. Nishida K, Kang JD, Gilbertson LG, et al. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of Adenovirus-mediated transfer of the human transforming growth factor beta-1 encoding gene. Spine. 1999;24:2419–2425
  38. LeMaitre CL, Hoyland JA, Freemont A. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study. Arthritis Res Ther. 2007;9:R83
  39. Levicoff EA, Kim JS, Sobajima S, et al. Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice. Spine. 2008;33:1509–1516(discussion 1517)
  40. Vadala G, Sowa GA, Smith L, et al. Regulation of transgene expression using an inducible system for improved safety of intervertebral disc gene therapy. Spine. 2007;32:1381–1387
  41. Iwashina T, Mochida J, Sakai D, et al. Feasibility of using a human nucleus pulposus cell line as a cell source in cell transplantation therapy for intervertebral disc degeneration. Spine. 2006;31:1177–1186
  42. Ganey TM, Meisel HJ, Hutton WC, Moos V, Libera J, Alasevic O. Autologous chondrocyte transplantation for disc repair. Presented at the 49th Annual Meeting of the Orthopaedic Research Society. New Orleans, LA, February 2-5 2003;
  43. Zhang YG, Guo X, Xu P, Kang LL, Li J. Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans. Clin Orthopaed Related Res. 2005;430:219–226
  44. Heuer F, Ulrich S, Claes L, et al. Biomechanical evaluation of conventional annulus fibrosus closure methods required for nucleus replacement. J NeurosurgSpine. 2008;9:307–313

PII: S1934-1482(09)00222-6

doi: 10.1016/j.pmrj.2009.02.011

PM&R
Volume 1, Issue 5 , Pages 466-470 , May 2009

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