PM&R
Volume 1, Issue 4 , Pages 335-339 , April 2009

Effectiveness of Levetiracetam in the Treatment of Lumbar Radiculopathy: An Open-Label Prospective Cohort Study

  • Maged S. Hamza, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University Health System, Richmond, VA
    • Corresponding Author InformationAddress correspondence to M.S.H., VCU Spine Center, 8700 Stony Point Parkway, Suite 260, Richmond, VA 23235
  • ,
  • David Greg Anderson, MD

      Affiliations

    • Department of Orthopedic Surgery, Thomas Jefferson University Hospitals, Philadelphia, PA
  • ,
  • John W. Snyder, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University Health System, Richmond, VA§
  • ,
  • Steven Deschner, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University Health System, Richmond, VA
  • ,
  • David X. Cifu, MD

      Affiliations

    • Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University Health System, Richmond, VA

Received 23 May 2008 ,Accepted 11 December 2008.

References 

  1. Woolf CJ, Mannion RJ. Neuropathic pain: Etiology, symptoms, mechanism, and management. Lancet. 1999;353:1959–1964
  2. Backonja MM. Anticonvulsants (antineuropathics) for neuropathic pain syndromes. Clin J Pain. 2000;16:S67–S72
  3. Bennett GJ. Neuropathic pain: New insight, new interventions. Hosp Pract. 1998;33:95–114
  4. Semenchuk MR, Sherman S. effectiveness of tizanidine in neuropathic pain: An open-label study. J Pain. 2000;1:285–292
  5. Dworkin RH, Backonja M, Rowbotham MC, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol. 2003;60:1524–1534
  6. Dworkin RH. An overview of neuropathic pain: syndromes, symptoms, signs, and several mechanisms. Clin J Pain. 2002;18:343–349
  7. Backonja MM. Use of anticonvulsants for treatment of neuropathic pain. Neurology. 2002;59:S14–S17
  8. Hansen HC. Treatment of chronic pain with antiepileptic drugs: A new era. South Med J. 1999;92:642–649
  9. Mcquay H, Carroll D, Jadad AR, et al. Anticonvulsant drugs for management of pain: A new systemic review. BMJ. 1995;311:1047–1052
  10. Kingery WS. A critical review of clinical trials for peripheral neuropathic pain and complex regional pain syndrome. Pain. 1997;73:123–139
  11. Patsalos PN. Pharmacokinetic profile of levetiracetam: Toward ideal characteristics. Pharmacol Ther. 2000;85:77–85
  12. Margineanu DG, Klitgaard H. Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classic antiepileptic drugs. Pharmacol Res. 2000;42:281–285
  13. Klitgaard H. Levetiracetam: The preclinical profile of a new class of antiepileptic drugs?. Epilepsia. 2001;42:13–18
  14. Shorvon SD, Lowenthal A, Janz D, et al. Multicenter, double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures (European Levetiracetam Study Group). Epilepsia. 2000;41:1179–1186
  15. Privitera M. Efficacy of levetiracetam: A review of three pivotal clinical trials. Epilepsia. 2001;42:31–35
  16. Harden C. Safety profile of levetiracetam. Epilepsia. 2001;42:36–39
  17. Browne TR, Szabo GK, Leppik IE, et al. Absence of pharmacokinetic drug interaction of levetiracetam with phenytoin in patients with epilepsy determined by new technique. J Clin Pharmacol. 2000;40:590–595
  18. UCB Pharma, Inc. Keppra® (levetiracetam) Tablets and Oral Solution Prescribing Information. http://keppra.comAccessed May 1, 2004
  19. Jenson M, Royal M, Mowa V, et al. Gabapentin and levetiracetam for the treatment of neuropathic pain: A prospective open label trial. Am J Pain Manage. 2001;11:125–128
  20. Rowbotham M, Manville N, Moreno-Lane M, et al. Prospective pilot study of Levetiracetam for post-herpetic neuralgia pain and allodynia. [Abstract] Neurology. 2003;4:71
  21. Dunteman E. Levetiracetam adjunctive analgesia in neoplastic plexopathies. [Abstract] J Pain. 2003;4:87
  22. Cochran J. Levetiracetam in cervical and lumbar radiculopathy: A pilot study. [Abstract] J Pain. 2003;4:89
  23. Price MJ. Levetiracetam in the treatment of neuropathic pain: Three case studies. Clin J Pain. 2004;20:33–36
  24. Krusz JC. Levetiracetam for chronic neuropathic pain treatment. [Abstract] J Pain. 2002;3:40
  25. Paterson S, Stewart S. Levetiracetam is effective in the treatment of chronic pain: a prospective open label case series. [Abstract] J Pain. 2003;4:89
  26. Rizzo M. Adjunctive levetiracetam therapy for myelopathic pain and paresthesias in MS. [Abstract] J Pain. 2003;4:79
  27. Pritchard D, Kearney B. Levetiracetam (Keppra): A community pain clinic experience with large numbers of patients with different types of pain. [Abstract] J Pain. 2003;4:90
  28. Empting L, Hughley Q, Millikin M. Levetiracetam in the treatment of traumatically induced sympathetic independent neuropathic pain, and post-operative radiculopathy. [Abstract] J Pain. 2003;4:84
  29. Cochran J. Levetiracetam (Keppra®) in neuropathic pain: A pilot study. [Abstract] J Pain. 2003;4:90
  30. Dillingham T, Lauder T, Andary M, et al. Identifying lumbosacral radiculopathies: An optimal electromyographic screen. Am J Phys Med Rehabil. 2000;79:496–503
  31. Daut RL, Cleeland CS, Flannery RC. Development of the Wisconsin brief pain questionnaire to assess pain in cancer and other disease. Pain. 1983;17:197–210
  32. Backonja MM, Stacey B. Neuropathic pain symptoms relative to overall pain rating. J Pain. 2004;5:491–497
  33. Freynhagen R, Grond S, Schüpfer G, et al. Efficacy and safety of pregabalin in treatment refractory patients with various neuropathic pain entities in clinical routine. Int J Clin Pract. 2007;61:1989–1996
  34. Semenchuk MR, Sherman S. Effectiveness of tizanidine in neuropathic pain: An open-label study. J Pain. 2000;1:285–292
  35. Ollat H, Cesaro P. Pharmacology of neuropathic pain. Clin Neuropharmacol. 1995;18:391–404
  36. Loscher W, Honack D. Development of tolerance during chronic treatment of kindled rats with the novel antiepileptic drug Levetiracetam. Epilepsia. 2000;41:1499–1506
  37. Sindrup SH, Jensen TS. Efficacy of pharmacological treatments of neuropathic pain; an update and effect related to mechanism of drug action. Pain. 1999;83:389–400

 Disclosure Key can be found on the Table of Contents and at www.pmrjournal.org

PII: S1934-1482(08)00085-3

doi: 10.1016/j.pmrj.2008.12.004

PM&R
Volume 1, Issue 4 , Pages 335-339 , April 2009